Antibiotic sensitivity of human genital mycoplasmas

The therapeutic failure of antimycoplasma drugs, subject to resistance is vital for specific microbiological investigation to overcome urogenital diseases among women. The susceptibility of 5 Mycoplasma hominis strains and 11 strains of Ureaplasma urealyticum were studied against six antibiotics namely: minocycline, lincomycin, erythromycin, tetracycline, doxycycline and rosaramicin. Both M. hominis and Ureaplasmas strains were highly resistant to tetracycline. It was observed that both rosaramicin and minocycline were active growth inhibitors for Ureaplasmas. However, erythromycin and lincomycin showed differential growth inhibitory patterns for M. hominis and Ureaplasma strains. In comparison, the minocycline and doxycycline exhibited similar antibiotic activity against Ureaplasma and M. hominis. The in vitro antibiotic sensitivity analysis for rosaramicin and erythromycin was also noted to be at the same level for all the isolates.