Highly sensitive non-enzymatic electrochemical glucose sensor surpassing water oxidation interference

An electrochemical non-enzymatic sensor based on a NiVP/Pi material was developed for the selective and sensitive determination of glucose. The novel sensor showed a high sensitivity of 6.04 mA mu M-1 cm(-2) with a lowest detection limit of 3.7 nM in a wide detection range of 100 nM-10 mM. The proposed sensor exhibited a superior selectivity without any interference from the oxygen evolution reaction during glucose sensing. We also found that this glucose sensor showed negligible interference from various interferents, such as ascorbic acid, uric acid, dopamine and sodium chloride. Additionally, a novel flexible sensor was developed by coating the NiVP/Pi over Whatman filter paper, which exhibited two linear ranges of 100 nM to 1 mu M and 100 mu M to 10 mM with an ultra-sensitivity of 1.130 mA mu M-1 cm(-2) and 0.746 mA mu M-1 cm(-2), respectively, in 0.1 M NaOH. The proposed sensor was tested with human blood serum samples demonstrating its practical application. Our findings provide a new route by fine tuning the composition of nickel and vanadium that sheds new light on better understanding the processes. This NiVP/Pi-based sensor offers a new approach towards the electrochemical detection of glucose, enabling glucose monitoring in a convenient way.