A convenient preparation of glycosyl chlorides from aryl/alkyl thioglycosides

被引：22
|
作者：
Sugiyama, S [1 ]
Diakur, JM [1 ]
机构：
[1] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada
来源：
ORGANIC LETTERS | 2000年 / 2卷 / 17期
关键词：
D O I：
10.1021/ol0063050
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Because of the vast structural diversity encountered in the field of glycobiology, versatile methods for orthogonal oligosaccharide assembly are always of interest. Reported herein is the preparation of glycosyl chloride donors obtained by reaction of the corresponding thioglycoside precursors with chlorosulfonium chloride reagent 4. The crude chlorides thus obtained can be used directly in subsequent glycosylation reactions, and examples of the generality of this approach are provided.
引用
收藏
页码：2713 / 2715
页数：3
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