SEXUAL DIMORPHISM IN SARS-COV-2 INFECTION

被引：3
|
作者：
Ulhaq, Z. S. [1 ]
Soraya, G. V. [2 ]
Zambrano, L. E. A. [3 ]
Garcia, C. P. [4 ]
机构：
[1] Maulana Malik Ibrahim State Islamic Univ Malang, Fac Med & Hlth Sci, Malang, East Java, Indonesia
[2] Hasanuddin Univ, Fac Med, Makassar, South Sulawesi, Indonesia
[3] Tech Univ Manabi, Fac Hlth Sci, Portoviejo, Manabi, Ecuador
[4] Weston Gen Hosp, Weston Super Mare, North Somerset, North Ireland
来源：
ACTA ENDOCRINOLOGICA-BUCHAREST | 2020年 / 16卷 / 04期
关键词：
Sexual dimorphism; estrogen; COVID-19; SARS-CoV-2; estrogen receptor; inflammatory mediator; ESTROGEN; EXPRESSION; TISSUE; ALPHA;
D O I：
10.4183/aeb.2020.522
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Previous studies have demonstrated that female patients with coronavirus disease 2019 (COVID-19) demonstrate more favorable prognosis relative to male patients. In this article, we elaborate the possible role of estrogen in the modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection severity. The potential interplay between several factors, including inherently lower estradiol (E-2) and slightly higher estrogen receptor beta (ER beta) levels in males, with inflammatory mediators are described. Altogether, there seems to be a sexually dimorphic response towards SARS-CoV-2 infection, and a possibility that COVID-19 severity is dependent on both E-2 levels and ER alpha:ER beta expression ratio in lymphoid and lung cells.
引用
收藏
页码：522 / 523
页数：2
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