Spatially addressable multiprotein nanoarrays templated by aptamer-tagged DNA nanoarchitectures

被引：232

作者：

Chhabra, Rahul

Sharma, Jaswinder

Ke, Yonggang

Liu, Yan

Rinker, Sherri

Lindsay, Stuart

Yan, Hao ^{[1
]}

机构：

[1] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA

[2] Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 34期

关键词：

D O I：

10.1021/ja072410u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we generalize a highly programmable strategy to self-assemble multiprotein nanoarrays with deterministic positional addressability. These protein nanoarrays were templated by aptamer-tagged DNA nanoarchitectures. Arrays of proteins with precisely controlled positions and interprotein spacings offer great potential in proteomics, tissue engineering, and medical diagnostics.

引用

页码：10304 / +

页数：3