18F-FDG and 18F-Florbetapir PET in Clinical Practice Regional Analysis in Mild Cognitive Impairment and Alzheimer Disease

被引:16
|
作者
Bailly, Matthieu [1 ,2 ]
Ribeiro, Maria Joao Santiago [2 ,3 ,4 ]
Vercouillie, Johny [3 ,4 ]
Hommet, Caroline [3 ,4 ,5 ]
Gissot, Valerie [6 ]
Camus, Vincent [3 ,4 ,5 ]
Guilloteau, Denis [2 ,3 ,4 ,7 ]
机构
[1] CHR Orleans, Nucl Med Unit, Tours, France
[2] CHRU Hop Tours, Hop Bretonneau, Tours, France
[3] INSERM, U930, Tours, France
[4] Univ Francois Rabelais Tours, Tours, France
[5] Hop Bretonneau, CMRR, Memory Clin, Tours, France
[6] CIC INSERM 1415, Tours, France
[7] CHRU Hop Tours, CIC IT INSERM, Tours, France
关键词
PET; F-18-AV45; florbetapir; F-18-FDG; MCI; Alzheimer disease; POSITRON-EMISSION-TOMOGRAPHY; POSTERIOR CINGULATE CORTEX; PITTSBURGH COMPOUND-B; BETA-AMYLOID BURDEN; GLUCOSE-METABOLISM; PIB-PET; F; 18; BRAIN; FLORBETAPIR; DEMENTIA;
D O I
10.1097/RLU.0000000000000666
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective: The aim of this study is to compare regional cerebral metabolic rate of glucose metabolism and amyloid-beta density in patients with Alzheimer disease (AD), mild cognitive impairment (MCI), and healthy elderly subjects. Methods: Eighteen patients (including 6 AD, 5 amnestic MCI, and 7 controls) were enrolled at the University Hospital of Tours, France, and submitted to clinical, neuropsychological, and MRI examinations. PET images using F-18-florbetapir (266 MBq) and F-18-FDG (185 MBq) were acquired. SUV ratios in specific regions were defined using PMOD3.2 software. Results: The mean values of F-18-FDG SUV ratio were significantly lower in frontal, anterior cingulate, and temporal regions in MCI patients than in normal elderly (-15%, -22%, and -11%, respectively). Alzheimer disease patients showed global cerebral metabolic rate of glucose metabolism decrease, especially in parietal and precuneus regions (-15% and -13% compared with healthy control subjects). Only precuneus cortex showed an increased F-18-florbetapir uptake in AD. There was no other significant regional difference in the amyloid-beta density. Conclusions: In this study, we observed regional brain metabolic changes between MCI, AD, and controls, whereas only precuneus showed an increased amyloid-beta density in AD. F-18-florbetapir PET analysis needs to be visual and global, whereas F-18-FDG analysis can be regional.
引用
收藏
页码:E111 / E116
页数:6
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