Recent advances in dynamic m6A RNA modification

被引：266
|
作者：
Cao, Guangchao [1 ]
Li, Hua-Bing [2 ]
Yin, Zhinan [1 ,3 ]
Flavell, Richard A. [2 ,4 ]
机构：
[1] Nankai Univ, Coll Life Sci, State Key Lab Medicinal Chem Biol, Tianjin 300071, Peoples R China
[2] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA
[3] Jinan Univ, Guangdong Prov Key Lab Mol Immunol & Antibody Eng, Biomed Translat Res Inst, Affiliated Hosp 1, Guangzhou 510632, Guangdong, Peoples R China
[4] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA
来源：
OPEN BIOLOGY | 2016年 / 6卷 / 04期
基金：
中国国家自然科学基金;
关键词：
m(6)A; mRNA; methylation; ARABIDOPSIS MESSENGER-RNA; FTO GENE; NUCLEAR-RNA; HNRNP C; SEQUENCE SPECIFICITY; NUCLEOTIDE-SEQUENCES; SECONDARY STRUCTURE; GLOBAL ANALYSIS; METHYLATION; OBESITY;
D O I：
10.1098/rsob.160003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The identification of m(6)A demethylases and high-throughput sequencing analysis of methylated transcriptome corroborated m(6)A RNA epigenetic modification as a dynamic regulation process, and reignited its investigation in the past few years. Many basic concepts of cytogenetics have been revolutionized by the growing understanding of the fundamental role of m(6)A in RNA splicing, degradation and translation. In this review, we summarize typical features of methylated transcriptome in mammals, and highlight the 'writers', 'erasers' and 'readers' of m(6)A RNA modification. Moreover, we emphasize recent advances of biological functions of m(6)A and conceive the possible roles of m(6)A in the regulation of immune response and related diseases.
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页数：8
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