Could we use a lower dose of rituximab to treat rheumatoid arthritis in clinical practice: pros and cons?

被引：2
|
作者：
Ferraccioli, Gianfranco [1 ,2 ]
Tolusso, Barbara [1 ,2 ]
Gremese, Elisa [1 ,2 ]
机构：
[1] Univ Cattolica Sacro Cuore, Sch Med, Inst Rheumatol, CIC Via Moscati 31, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Fdn Policlin Gemelli, Inst Rheumatol, CIC Via Moscati 31, I-00168 Rome, Italy
来源：
ARTHRITIS RESEARCH & THERAPY | 2016年 / 18卷
关键词：
Rituximab; Low dose; High dose; Synovial tissue B cell depletion; Peripheral B cell depletion; EFFICACY; TRIAL; METHOTREXATE; SAFETY;
D O I：
10.1186/s13075-016-1022-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The CERERRA database provides evidence that low-dose rituximab performs as well as the conventional dose in the real world, thus highlighting the possible pharmacoeconomic impact. In clinical trials, it has been shown that rituximab 500 mg twice, performs as well as 1 g twice, 2 weeks apart, in terms of the American College of Rheumatology (ACR) 20 and ACR50, but not the ACR70. The choice should always be made after considering that the IMAGE trial has demonstrated similar radiographic progression after the first 6 months, but with less control, with low-dose rituximab in the first 6 months. A possible alternative can be hypothesized.
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页数：3
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