Identification of a novel allele HLA-B*5610 in a Chinese potential bone marrow donor

被引：10
|
作者：
Wu, GG
Cheng, LH
Zhou, D
Deng, ZH
Zou, HY
Wei, TL
Li, Z
Li, DC
Gao, SQ
Zhao, TM
机构：
[1] NIAID, Mol & Cellular Immunogenet Sect, NIH, Bethesda, MD 20892 USA
[2] Shenzhen Inst Transfus Med, Shenzhen, Peoples R China
来源：
TISSUE ANTIGENS | 2003年 / 61卷 / 03期
关键词：
cloning of HLA-B*5610; HLA-B allele; PCR-SSP; point mutation;
D O I：
10.1034/j.1399-0039.2003.00031.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A novel HLA-B allele, B*5610, has been identified in a potential bone marrow donor, his mother and brother using DNA-based typing and molecular cloning methods. The B*5610 allele differs from the closest matching HLA sequence of B*5602 by two nucleotide substitutions in exon 3, 559 C-->A and 560 T-->C, resulting in an amino acid change from Leu (CTG) to Thr (ACG) at codon 187. This new allele was segregated together with A*24020101 and DRB1*140101 in the proband's family. Serology study revealed that B*5610 is associated with B22 specificity. A PCR-SSP method was developed to distinguish B*5610 from other B*56 alleles. No further individuals with B*5610 were detected in 5000 Chinese bone marrow blood donors.
引用
收藏
页码：256 / 258
页数：3
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