Magnetic and inductive heating properties of Fe3O4/polyethylene glycol composite nanoparticles with core-shell structure

被引：60
|
作者：
Zhao, Dong-Lin [1 ]
Teng, Pan [2 ]
Xu, Ying [1 ]
Xia, Qi-Sheng [3 ]
Tang, Jin-Tian [4 ]
机构：
[1] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
[2] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
[3] China Japan Friendship Hosp, Inst Clin Med Sci, Beijing 100029, Peoples R China
[4] Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China
来源：
JOURNAL OF ALLOYS AND COMPOUNDS | 2010年 / 502卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Nanostructures; Nanofabrications; Scanning and transmission electron microscopy; X-ray diffraction; Magnetic measurements; FE3O4; NANOPARTICLES; HYPERTHERMIA; DRUG; MICROSPHERES; ENHANCEMENT; PARTICLES; DEXTRAN; FUTURE; CELLS; FIELD;
D O I：
10.1016/j.jallcom.2010.04.177
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The magnetite (Fe3O4) nanoparticles were prepared by coprecipitation of Fe3+ and Fe2+ using ammonium hydroxide (NH4OH) as a precipitating agent. The Fe3O4/polyethylene glycol (PEG) magnetic composite nanoparticles with a core-shell structure with a diameter of 10-40 nm were prepared by two step additions of the primary and the secondary surfactants, respectively. The inductive heat property of Fe3O4/PEG composite nanoparticles in an alternating current (AC) magnetic field was investigated. The potential of Fe3O4/PEG nanoparticles was evaluated for localized hyperthermia treatment of cancers. The saturation magnetization, Ms, and coercivity, Hc, are 67.06 emu g(-1) and 7 Oe for Fe3O4 nanoparticles and 64.11 emu g(-1) and 14 Oe for Fe3O4/PEG composite nanoparticles, respectively. Exposed in the AC magnetic field for 100 s, the temperatures of physiological saline suspensions containing Fe3O4 nanoparticles or Fe3O4/PEG composite nanoparticles are 89.2 degrees C and 72.2 degrees C, respectively. The Fe3O4/PEG composite nanoparticles will be useful as good thermoseeds for localized hyperthermia treatment of cancers. (C) 2010 Elsevier BM. All rights reserved.
引用
收藏
页码：392 / 395
页数：4
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