Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease: Results from an Open-Label, Phase I Trial

被引:0
|
作者
Muramatsu, Shin-Ichi [1 ]
Fujimoto, Ken-Ichi [1 ]
Kato, Seiya [1 ]
Asari, Sayaka [1 ]
Mizukami, Hiroaki [1 ]
Ikeguchi, Kunihiko [1 ]
Kawakami, Tadataka [1 ]
Urabe, Masashi [1 ]
Kume, Akihiro [1 ]
Sato, Toshihiko [2 ]
Watanabe, Eiju [1 ]
Ozawa, Keiya [1 ]
Nakano, Imaharu [1 ]
机构
[1] Jichi Med Univ, Shimotsuke, Japan
[2] Utsunomiya Cent Clin, Utsunomiya, Tochigi, Japan
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
引用
收藏
页码:S168 / S168
页数:1
相关论文
共 50 条
  • [1] A Phase I Study of Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease
    Muramatsu, Shin-ichi
    Fujimoto, Ken-ichi
    Kato, Seiya
    Mizukami, Hiroaki
    Asari, Sayaka
    Ikeguchi, Kunihiko
    Kawakami, Tadataka
    Urabe, Masashi
    Kume, Akihiro
    Sato, Toshihiko
    Watanabe, Eiju
    Ozawa, Keiya
    Nakano, Imaharu
    MOLECULAR THERAPY, 2010, 18 (09) : 1731 - 1735
  • [2] Aromatic L-amino acid decarboxylase gene transfer therapy for Parkinson's disease: Initial results of an open-label, dose escalation, safety and tolerability study
    Christine, C.
    Starr, P. A.
    Larson, P.
    Mah, R.
    Eberling, J.
    Jagust, W.
    Aminoff, M. A.
    MOVEMENT DISORDERS, 2006, 21 : S399 - S400
  • [3] Aromatic L-amino acid decarboxylase gene transfer therapy for Parkinson's disease: Initial results of an open-label, dose escalation, safety and tolerability study
    Christine, CW
    Starr, PA
    Larson, P
    Mah, R
    Eberling, J
    Jagust, W
    McGuire, D
    Aminoff, MJ
    NEUROLOGY, 2006, 66 (05) : A185 - A185
  • [4] AROMATIC L-AMINO ACID DECARBOXYLASE GENE TRANSFER FOR PARKISON'S DISEASE: PRELIMINARY RESULTS OF AN OPEN-LABEL SAFETY STUDY
    Muramatsu, Shin-ichi
    Fujimoto, Ken-ichi
    Kato, Seiya
    Mizukami, Hiroaki
    Ikeguchi, Kunihiko
    Kawakami, Tadataka
    Urabe, Masashi
    Kume, Akihiro
    Sato, Toshihiko
    Watanabe, Eiju
    Ozawa, Keiya
    Nakano, Imaharu
    JOURNAL OF GENE MEDICINE, 2009, 11 (12): : 1151 - 1152
  • [5] A PHASE I STUDY OF AROMATIC L-AMINO ACID DECARBOXYLASE GENE THERAPY FOR PARKINSON7S DISEASE
    Muramatsu, Shin-ichi
    JOURNAL OF GENE MEDICINE, 2014, 16 (7-8): : 218 - 218
  • [6] A phase 1 trial of gene delivery of aromatic L-amino acid decarboxylase for Parkinson disease
    Muramatsu, Shin-ichi
    Fujimoto, Ken-ichi
    Kato, Seiya
    Asari, Sayaka
    Mizukami, Hiroaki
    Sato, Toshihiko
    Watanabe, Eiju
    Ozawa, Keiya
    Nakano, Imaharu
    NEUROSCIENCE RESEARCH, 2009, 65 : S24 - S24
  • [7] PET assessment of the aromatic L-amino acid decarboxylase gene expression in a phase I gene therapy study for Parkinson's disease
    Asari, S.
    Fujimoto, K.
    Kato, S.
    Mizukami, H.
    Ikeguchi, K.
    Kawakami, T.
    Urabe, M.
    Watanabe, E.
    Sato, T.
    Ozawa, K.
    Nakano, I.
    Muramatsu, S.
    MOVEMENT DISORDERS, 2011, 26 : S120 - S120
  • [8] PHASE I TRIAL OF AAV VECTOR-MEDIATED GENE DELIVERY OF AROMATIC L-AMINO ACID DECARBOXYLASE FOR PARKINSON'S DISEASE
    Muramatsu, Shin-ichi
    Fujimoto, Ken-ichi
    Kato, Seiya
    Asari, Sayaka
    Mizukami, Hiroaki
    Ikeguchi, Kunihiko
    Kawakami, Tadataka
    Urabe, Masashi
    Kume, Akihiro
    Sato, Toshihiko
    Watanabe, Eiju
    Ozawa, Keiya
    Nakano, Ima-haru
    JOURNAL OF GENE MEDICINE, 2010, 12 (12): : 1024 - 1024
  • [9] Aromatic L-Amino Acid Decarboxylase Gene Therapy Enhances Levodopa Response in Parkinson's Disease
    Nutt, John G.
    Curtze, Carolin
    Hiller, Amie
    Anderson, Shannon
    Larson, Paul S.
    Van Laar, Amber D.
    Richardson, R. Mark
    Thompson, Marin E.
    Sedkov, Alexander
    Leinonen, Mika
    Ravina, Bernard
    Bankiewicz, Krystof S.
    Christine, Chadwick W.
    MOVEMENT DISORDERS, 2020, 35 (05) : 851 - 858
  • [10] Aromatic L-amino acid decarboxylase modulation and Parkinson's disease
    Neff, NH
    Hadjiconstantinou, M
    CURRENT NEUROCHEMICAL AND PHARMACOLOGICAL ASPECTS OF BIOGENIC AMINES, 1995, 106 : 91 - 97