Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy

被引：8
|
作者：
Chao, Tung-Bo [1 ,2 ]
Li, Chien-Feng [3 ,4 ,5 ,6 ]
Lin, Ching-Yih [7 ,8 ]
Tian, Yu-Feng [9 ,10 ]
Chang, I-Wei [11 ]
Sheu, Ming-Jen [7 ]
Lee, Ying-En [12 ,13 ]
Chan, Ti-Chun [3 ]
He, Hong-Lin [11 ,14 ]
机构：
[1] Yuans Gen Hosp, Dept Colorectal Surg, Kaohsiung, Taiwan
[2] Meiho Univ, Dept Hlth Business Adm, Pingtung, Taiwan
[3] Chi Mei Med Ctr, Dept Pathol, Tainan, Taiwan
[4] Natl Hlth Res Inst, Natl Inst Canc Res, Tainan, Taiwan
[5] Southern Taiwan Univ Sci & Technol, Dept Biotechnol, Tainan, Taiwan
[6] Kaohsiung Med Univ, Inst Clin Med, Kaohsiung, Taiwan
[7] Chi Mei Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol, Tainan, Taiwan
[8] Southern Taiwan Univ Sci & Technol, Dept Leisure Recreat & Tourism Management, Tainan, Taiwan
[9] Chi Mei Med Ctr, Dept Surg, Div Gen Surg, Tainan, Taiwan
[10] Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr, Tainan, Taiwan
[11] I Shou Univ, E DA Hosp, Dept Pathol, Kaohsiung, Taiwan
[12] Kaohsiung Chang Gung Mem Hosp, Dept Anesthesiol, Kaohsiung, Taiwan
[13] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan
[14] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung 80424, Taiwan
来源：
FUTURE ONCOLOGY | 2016年 / 12卷 / 12期
关键词：
chemoradiotherapy; DSG3; rectal cancer; PATHOLOGICAL COMPLETE RESPONSE; TOTAL MESORECTAL EXCISION; PEMPHIGUS-VULGARIS; CELL-ADHESION; CANCER CELLS; DESMOGLEIN; NECK-CANCER; FOLLOW-UP; EXPRESSION; RADIOTHERAPY;
D O I：
10.2217/fon-2016-0071
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: This study aimed to investigate the prognostic significance of DSG3 and its association with response to neoadjuvant concurrent chemoradiotherapy (CCRT) in rectal cancer. Materials & methods: Data mining of a publicly available dataset was performed to find genes associated with CCRT response. Immunohistochemistry was applied to evaluate DSG3 expression. The relationships between DSG3 expression and various clinicopathological parameters and survival were analyzed. Results: The DSG3 gene was significantly associated with CCRT response. The expression of DSG3 negatively correlated with poorer tumor regression (p < 0.001) and had an independent negative impact on disease-specific survival (p = 0.011), local recurrence-free survival (p = 0.031) and metastasis-free survival (p = 0.029). Conclusion: DSG3 was a key prognostic factor and predictor for CCRT response in rectal cancer patients.
引用
收藏
页码：1457 / 1467
页数：11
相关论文
共 50 条
  • [1] Prognostic significance of circumferential margin involvement in rectal adenocarcinoma treated with preoperative chemoradiotherapy and low anterior resection
    Luna-Pérez, P
    Bustos-Cholico, E
    Alvarado, I
    Maffuz, A
    Rodríguez-Ramírez, S
    De La Barrera, MG
    Labastida, S
    JOURNAL OF SURGICAL ONCOLOGY, 2005, 90 (01) : 20 - 25
  • [2] ANALYSIS OF PROGNOSTIC FACTORS OF SURVIVAL IN RECTAL ADENOCARCINOMA PATIENTS TREATED WITH PREOPERATIVE CHEMORADIOTHERAPY.
    Saad, S. S.
    DISEASES OF THE COLON & RECTUM, 2020, 63 (06) : E235 - E235
  • [3] Do pathological variables have prognostic significance in rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and surgery?
    Luca Reggiani Bonetti
    Simona Lionti
    Federica Domati
    Valeria Barresi
    World Journal of Gastroenterology, 2017, 23 (08) : 1412 - 1423
  • [4] Do pathological variables have prognostic significance in rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and surgery?
    Bonetti, Luca Reggiani
    Lionti, Simona
    Domati, Federica
    Barresi, Valeria
    WORLD JOURNAL OF GASTROENTEROLOGY, 2017, 23 (08) : 1412 - 1423
  • [5] Molecular prognostic factors in rectal cancer treated by preoperative chemoradiotherapy
    Nam, Taek-Keun
    Lee, Ji-Shin
    Kim, Hyeong-Rok
    Ahn, Sung-Ja
    Song, Ju-Young
    Yoon, Mee Sun
    ONCOLOGY LETTERS, 2010, 1 (01) : 23 - 29
  • [6] Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer
    Rödel, C
    Martus, P
    Papadoupolos, T
    Füzesi, L
    Klimpfinger, M
    Fietkau, R
    Liersch, T
    Hohenberger, W
    Raab, R
    Sauer, R
    Wittekind, C
    JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (34) : 8688 - 8696
  • [7] Clinical significance of mucinous rectal adenocarcinoma following preoperative chemoradiotherapy and curative surgery
    Kim, Tae Gyu
    Park, Won
    Choi, Doo Ho
    Park, Hee Chul
    Kim, Seok-Hyung
    Cho, Yong Beom
    Yun, Seong Hyeon
    Kim, Hee Cheol
    Lee, Woo Yong
    Lee, Jeeyun
    Park, Joon Oh
    Park, Young Suk
    Lim, Ho Yeong
    Kang, Won Ki
    Chun, Ho-Kyung
    TUMORI JOURNAL, 2016, 102 (01): : 114 - 121
  • [8] Predictors of sensitivity to preoperative chemoradiotherapy of rectal adenocarcinoma
    Yan, Hongjiang
    Wang, Renben
    Zhu, Kunli
    Zhao, Wei
    Jiang, Shumei
    Feng, Rui
    Xu, Xiaoqing
    Meng, Xiangjiao
    Sun, Huiying
    Zhang, Haiqin
    Mu, Dianbin
    Xu, Zhongfa
    TUMORI JOURNAL, 2011, 97 (06): : 717 - 723
  • [9] Prognostic significance of nodal disease following preoperative radiation for rectal adenocarcinoma
    Rinkus, KM
    Russell, GB
    Levine, EA
    AMERICAN SURGEON, 2002, 68 (05) : 482 - 487
  • [10] Does the depth of mesorectal invasion have prognostic significance in patients with ypT3 lower rectal cancer treated with preoperative chemoradiotherapy?
    Ogura, Atsushi
    Akiyoshi, Takashi
    Yamamoto, Noriko
    Kawachi, Hiroshi
    Ishikawa, Yuichi
    Noma, Hisashi
    Nagino, Masato
    Fukunaga, Yosuke
    Ueno, Masashi
    INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2017, 32 (03) : 349 - 356
12345