Pd-catalyzed Kumada-Corriu cross-coupling reactions at low temperatures allow the use of Knochel-type Grignard reagents

被引：158
|
作者：
Martin, Ruben [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 13期
关键词：
D O I：
10.1021/ja070830d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A catalyst system able to operate at temperatures as low as -65 degrees C for the Pd-catalyzed Kumada-Corriu cross-coupling reaction is described. This unprecedented level of activity allows the use of highly functionalized (Knochel-type) Grignard reagents. Additionally, the tolerance of the protocol toward a wide variety of functional groups allows for the synthesis of valuable compounds, including heterocyclic or polyfluoro biaryls.
引用
收藏
页码：3844 / +
页数：3
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