Pediatric Brain Tumors: Current Knowledge and Therapeutic Opportunities

被引：22
|
作者：
Glod, John [4 ]
Rahme, Gilbert J. [1 ,3 ]
Kaur, Harpreet [5 ,6 ,7 ]
Raabe, Eric H. [5 ,6 ,7 ]
Hwang, Eugene I. [8 ,9 ]
Israel, Mark A. [1 ,2 ,3 ]
机构：
[1] Dartmouth Coll, Hitchcock Med Ctr, Norris Cotton Canc Ctr, Dept Genet, Hanover, NH 03756 USA
[2] Dartmouth Coll, Hitchcock Med Ctr, Norris Cotton Canc Ctr, Dept Pediat, Hanover, NH 03756 USA
[3] Dartmouth Coll, Hitchcock Med Ctr, Norris Cotton Canc Ctr, Geisel Sch Med Dartmouth, Hanover, NH 03756 USA
[4] NCI, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA
[5] Johns Hopkins Sch Med, Div Neuropathol, Bloomberg Childrens Hosp, Baltimore, MD USA
[6] Johns Hopkins Sch Med, Sidney Kimmel Comprehens Canc Ctr, Bloomberg Childrens Hosp, Baltimore, MD USA
[7] Johns Hopkins Sch Med, Div Pediat Oncol, Bloomberg Childrens Hosp, Baltimore, MD USA
[8] Childrens Natl Med Ctr, Brain Tumor Inst, Washington, DC 20010 USA
[9] Childrens Natl Med Ctr, Div Hematol Oncol, Washington, DC 20010 USA
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2016年 / 38卷 / 04期
基金：
美国国家卫生研究院;
关键词：
pediatric glioma; medulloblastoma; diffuse intrinsic pontine glioma; ependymoma; SEGA; HIGH-GRADE GLIOMAS; INTRINSIC PONTINE GLIOMA; GIANT-CELL ASTROCYTOMA; MAPK PATHWAY ACTIVATION; PHASE-II; TUBEROUS SCLEROSIS; MYXOPAPILLARY EPENDYMOMA; RECURRENT EPENDYMOMA; CHILDHOOD MEDULLOBLASTOMA; MOLECULAR CLASSIFICATION;
D O I：
10.1097/MPH.0000000000000551
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Great progress has been made in many areas of pediatric oncology. However, tumors of the central nervous system (CNS) remain a significant challenge. A recent explosion of data has led to an opportunity to understand better the molecular basis of these diseases and is already providing a foundation for the pursuit of rationally chosen therapeutics targeting relevant molecular pathways. The molecular biology of pediatric brain tumors is shifting from a singular focus on basic scientific discovery to a platform upon which insights are being translated into therapies.
引用
收藏
页码：249 / 260
页数：12
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