Colistin Resistance Mediated by mcr-1 in ESBL-Producing, Multidrug Resistant Salmonella Infantis in Broiler Chicken Industry, Italy (2016-2017)

被引：43

作者：

Carfora, Virginia ^{[1
]}

Alba, Patricia ^{[1
]}

Leekitcharoenphon, Pimlapas ^{[2
]}

Ballaro, Daniele ^{[1
]}

Cordaro, Gessica ^{[1
]}

Di Matteo, Paola ^{[1
]}

Donati, Valentina ^{[1
]}

Ianzano, Angela ^{[1
]}

Iurescia, Manuela ^{[1
]}

Stravino, Fiorentino ^{[1
]}

Tagliaferri, Tania ^{[1
]}

Battisti, Antonio ^{[1
]}

Franco, Alessia ^{[1
]}

机构：

[1] Ist Zooprofilatt Sperimentale Lazio & Toscana M A, Gen Diagnost Dept, Natl Reference Lab Antimicrobial Resistance, Rome, Italy

[2] Tech Univ Denmark, Natl Food Inst, WHO Collaborating Ctr Antimicrobial Resistance Fo, European Union Reference Lab Antimicrobial Resist, Lyngby, Denmark

来源：

FRONTIERS IN MICROBIOLOGY | 2018年 / 9卷

关键词：

colistin resistance; mcr genes; ESBL (Extended Spectrum Beta-Lactamases); plasmids; whole genome sequencing; Salmonella Infantis; broilers; broiler meat; IDENTIFICATION; SYSTEMS;

D O I：

10.3389/fmicb.2018.01880

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Colistin-resistance mediated by mobilisable and plasmid-borne mcr genes has emerged worldwide, threatening the efficacy of colistin, a last resort antibiotic increasingly used for treating human invasive infections by multidrug-resistant or extensively drug-resistant Enterobacteriaceae. In this study, we report the first evidence of mcr-1-mediated colistin resistance in four multidrug resistant (MDR) out of 324 Salmonella infantis from the Italian antimicrobial resistance (AMR) monitoring (2001-2017) in broilers and broiler meat. Two were also Extended Spectrum Beta-Lactamases (ESBL)-producing isolates. Characterization by whole genome sequencing (WGS), located mcr-1.1 on an incX4 plasmid. Phylogenetic analysis of these isolates with selected Italian S. Infantis previously isolated from animals, meat and human clinical cases with unknown epidemiological relationship, demonstrated that ESBL-producing, mcr-1-positive isolates belonged to the emerging pESI-like-positive-ESBL-producing clone described in Italy in 2015.

引用

页数：6

共 16 条

[1] Colistin Resistance Mediated by mcr-1 in ESBL-Producing, Multidrug Resistant Salmonella Infantis in Broiler Chicken Industry, Italy (2016-2017) (vol 9, 1880, 2018)
Carfora, Virginia
Alba, Patricia
Leekitcharoenphon, Pimlapas
Ballaro, Daniele
Cordaro, Gessica
Di Matteo, Paola
Donati, Valentina
Ianzano, Angela
Iurescia, Manuela
Stravino, Fiorentino
Tagliaferri, Tania
Battisti, Antonio
Franco, Alessia
[J]. FRONTIERS IN MICROBIOLOGY, 2018, 9
[2] mcr-1-Mediated Colistin Resistance and Genomic Characterization of Antimicrobial Resistance in ESBL-Producing Salmonella Infantis Strains from a Broiler Meat Production Chain in Italy
Proietti, Patrizia Casagrande
Musa, Laura
Stefanetti, Valentina
Orsini, Massimiliano
Toppi, Valeria
Branciari, Raffaella
Blasi, Francesca
Magistrali, Chiara Francesca
Capomaccio, Stefano
Kika, Tana Shtylla
Franciosini, Maria Pia
[J]. ANTIBIOTICS-BASEL, 2022, 11 (06):
[3] mcr-1 Colistin Resistance in ESBL-Producing Klebsiella pneumoniae, France
Caspar, Yvan
Maillet, Mylene
Pavese, Patricia
Francony, Gilles
Brion, Jean-Paul
Mallaret, Marie-Reine
Bonnet, Richard
Robin, Frederic
Beyrouthy, Racha
Maurin, Max
[J]. EMERGING INFECTIOUS DISEASES, 2017, 23 (05) : 874 - 876
[4] First report from supermarket chicken meat and genomic characterization of colistin resistance mediated by mcr-1.1 in ESBL-producing, multidrug-resistant Salmonella Minnesota
Habib, Ihab
Elbediwi, Mohammed
Ghazawi, Akela
Mohamed, Mohamed-Yousif Ibrahim
Lakshmi, Glindya Bhagya
Khan, Mushtaq
[J]. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 2022, 379
[5] Emergence of a Clonal Lineage of Multidrug-Resistant ESBL-Producing Salmonella Infantis Transmitted from Broilers and Broiler Meat to Humans in Italy between 2011 and 2014
Franco, Alessia
Leekitcharoenphon, Pimlapas
Feltrin, Fabiola
Alba, Patricia
Cordaro, Gessica
Iurescia, Manuela
Tolli, Rita
D'Incau, Mario
Staffolani, Monica
Di Giannatale, Elisabetta
Hendriksen, Rene S.
Battisti, Antonio
[J]. PLOS ONE, 2015, 10 (12):
[6] Colistin resistance gene mcr-1 harboured on a multidrug resistant plasmid (vol 16, pg 283, 2016)
Malhotra-Kumar, S.
Xavier, B. B.
Das, A. J.
Lammens, C.
Butaye, P.
Goossens, H.
[J]. LANCET INFECTIOUS DISEASES, 2016, 16 (03): : 279 - 279
[7] Molecular Detection of Colistin Resistance mcr-1 Gene in Multidrug-Resistant Escherichia coli Isolated from Chicken
Uddin, Md Bashir
Alam, Mohammad Nurul
Hasan, Mahmudul
Hossain, S. M. Bayejed
Debnath, Mita
Begum, Ruhena
Samad, Mohammed A.
Hoque, Syeda Farjana
Chowdhury, Md. Shahidur Rahman
Rahman, Md. Mahfujur
Hossain, Md. Mukter
Hassan, Mohammad Mahmudul
Lundkvist, Ake
Jarhult, Josef D.
El Zowalaty, Mohamed E.
Ahmed, Syed Sayeem Uddin
[J]. ANTIBIOTICS-BASEL, 2022, 11 (01):
[8] Resistance to Colistin Mediated by mcr-1 among Multidrug Resistant Gram Negative Pathogens at a Tertiary Care Hospital, Egypt
Shabban, Marwa
Fahim, Noha Alaa Eldin
Montasser, Karim
El Magd, Nagwa M. Abo
[J]. JOURNAL OF PURE AND APPLIED MICROBIOLOGY, 2020, 14 (02): : 1125 - 1132
[9] Emergence of IncHI2 Plasmids With Mobilized Colistin Resistance (mcr)-9 Gene in ESBL-Producing, Multidrug-Resistant Salmonella Typhimurium and Its Monophasic Variant ST34 From Food-Producing Animals in Italy
Diaconu, Elena Lavinia
Alba, Patricia
Feltrin, Fabiola
Di Matteo, Paola
Iurescia, Manuela
Chelli, Eleonora
Donati, Valentina
Marani, Ilaria
Giacomi, Angelo
Franco, Alessia
Carfora, Virginia
[J]. FRONTIERS IN MICROBIOLOGY, 2021, 12
[10] Characterization of ESBL-producing Escherichia spp. and report of an mcr-1 colistin-resistance Escherichia fergusonni strain from minced meat in Pamplona, Colombia
Martins, Joana C. L.
Pintor-Cora, Alberto
Alegria, Angel
Santos, Jesus A.
Herrera-Arias, Fanny
[J]. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 2023, 394

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