In vitro evaluation of the activity of aromatic nitrocompounds against Trypanosoma cruzi

被引：17
|
作者：
Oliveira, RB
Passos, APF
Alves, RO
Romanha, AJ
Prado, MAF
de Souza, JD
Alves, RJ
机构：
[1] Univ Fed Minas Gerais, Fac Farm, BR-30180112 Belo Horizonte, MG, Brazil
[2] Fiocruz MS, Ctr Pesquisas Rene Rachou, Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Dept Quim, Belo Horizonte, MG, Brazil
来源：
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2003年 / 98卷 / 01期
关键词：
nitrocompounds; Trypanosoma cruzi; bloodstream forms;
D O I：
10.1590/S0074-02762003000100018
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Fourteen compounds were evaluated for their activity against Trypanosoma cruzi blood stream forms at the concentration of 500 mug/ml. Six compounds were active and re-tested at lower concentrations.
引用
收藏
页码：141 / 144
页数：4
相关论文
共 50 条
  • [1] Aromatic guanyl hydrazones: Synthesis, structural studies and in vitro activity against Trypanosoma cruzi
    Messeder, JC
    Tinoco, LW
    FigueroaVillar, JD
    Souza, EM
    Rita, RS
    deCastro, SL
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (24) : 3079 - 3084
  • [2] Activity of "reversed" diamidines against Trypanosoma cruzi "in vitro"
    Silva, C. F.
    Batista, Marcos Meuser
    Mota, Renata Alves
    de Souza, Elen Mello
    Stephens, Chad E.
    Som, Phanneth
    Boykin, David Wilson
    Soeiro, Maria de Nazare C.
    BIOCHEMICAL PHARMACOLOGY, 2007, 73 (12) : 1939 - 1946
  • [3] In Vitro Evaluation of Synthetic Flavones Against Trypanosoma cruzi
    Andrade, Josimara Souza
    de Abreu, Leonardo Gomes
    Sales Junior, Policarpo Ademar
    Fonseca Murta, Silvane Maria
    Taylor, Jason Guy
    REVISTA VIRTUAL DE QUIMICA, 2021, 13 (01) : 146 - 155
  • [4] Phenotypic Screening In Vitro of Novel Aromatic Amidines against Trypanosoma cruzi
    Simoes-Silva, M. R.
    Nefertiti, A. S. G.
    De Araujo, J. S.
    Batista, M. M.
    Da Silva, P. B.
    Bahia, M. T.
    Menna-Barreto, R. S.
    Pavao, B. P.
    Green, J.
    Farahat, A. A.
    Kumar, A.
    Boykin, D. W.
    Soeiro, M. N. C.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (08) : 4701 - 4707
  • [5] In vitro study of the trypanocidal activity of anilinophenanthrolines against Trypanosoma cruzi
    Zuma, Aline Araujo
    da Silva, Ramon Borges
    Garden, Simon J.
    de Souza, Wanderley
    PARASITOLOGY INTERNATIONAL, 2021, 83
  • [6] In vitro activity of Etanidazole against the protozoan parasite Trypanosoma cruzi
    Petray, PB
    Morilla, MJ
    Corral, RS
    Romero, EL
    MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2004, 99 (02): : 233 - 235
  • [7] ASSESSING IN VITRO AND IN VIVO ACTIVITY OF MILTEFOSINE AGAINST TRYPANOSOMA CRUZI
    Gulin, Julian E.
    Altcheh, Jaime
    Bisio, Margarita
    Rocco, Daniela M.
    Solana, Maria E.
    Garcia-Bournissen, Facundo
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2017, 95 (05): : 398 - 398
  • [8] In Vitro, In Silico, and In Vivo Analyses of Novel Aromatic Amidines against Trypanosoma cruzi
    Santos, Camila C.
    Lionel, Jessica R.
    Peres, Raiza B.
    Batista, Marcos M.
    da Silva, Patricia B.
    de Oliveira, Gabriel M.
    da Silva, Cristiane F.
    Batista, Denise G. J.
    Souza, Sandra Maria O.
    Andrade, Carolina H.
    Neves, Bruno J.
    Braga, Rodolpho C.
    Patrick, Donald A.
    Bakunova, Svetlana M.
    Tidwell, Richard R.
    Soeiro, Maria de Nazare C.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018, 62 (02)
  • [9] In vitro and in vivo trypanocidal activity of a benzofuroxan derivative against Trypanosoma cruzi
    Petry, Leticia dos Santos
    Pillar Mayer, Joao Candido
    de Giacommeti, Marjorie
    de Oliveira, Dionatan Teixeira
    Garzon, Litierria Razia
    Engelmann, Ana Martiele
    Igor Magalhaes de Matos, Antonio Francisco
    Baldissera, Matheus Dellamea
    Dornelles, Luciano
    de Andrade, Cinthia Melazzo
    Monteiro, Silvia Gonzalez
    EXPERIMENTAL PARASITOLOGY, 2021, 226
  • [10] In vitro activity of Rutaceae species against the trypomastigote form of Trypanosoma cruzi
    Mafezoli, J
    Vieira, PC
    Fernandes, JB
    da Silva, MFGF
    de Albuquerque, S
    JOURNAL OF ETHNOPHARMACOLOGY, 2000, 73 (1-2) : 335 - 340
12345