Computational proteomics: High-throughput analysis for systems biology

High-throughput proteomics is a rapidly developing field that offers the global profiling of proteins from a biological system. These high-throughput technological advances are fueling a revolution in biology, enabling analyses at the scale of entire systems (e.g., whole cells, tumors, or environmental communities). However, simply identifying the proteins in a cell is insufficient for understanding the underlying complexity and operating mechanisms of the overall system. Systems level investigations generating large-scale global data are relying more and more on computational analyses, especially in the field of proteomics.