CANCER THERAPY Targeting drug-resistant mutations in ALK

被引：2
|
作者：
He, Liu [1 ,2 ]
Dar, Arvin C. [1 ,2 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Oncol Sci, Tisch Canc Inst, Mt Sinai Ctr Therapeut Discovery, New York, NY 10029 USA
[2] Icahn Sch Med Mt Sinai, Dept Pharmacol Sci, Tisch Canc Inst, Mt Sinai Ctr Therapeut Discovery, New York, NY 10029 USA
来源：
NATURE CANCER | 2022年 / 3卷 / 06期
关键词：
INHIBITOR;
D O I：
10.1038/s43018-022-00390-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Therapy resistance limits the clinical success of tyrosine kinase inhibitors (TKIs) in ALK-positive non-small cell lung cancer. A study now proposes a framework to identify compound resistance mutations to the lorlatinib TKI and provides structure-based drug design approaches to overcome resistance mediated by ALK(G1202R) or ALK(I1171N/S/T).
引用
收藏
页码：659 / 661
页数：3
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