Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain

被引：107

作者：

Perrin, Amandine ^{[1
,2
,3
]}

Larsonneur, Elise ^{[1
,2
,4
]}

Nicholson, Ainsley C. ^{[5
]}

Edwards, David J. ^{[6
,7
]}

Gundlach, Kristin M. ^{[8
]}

Whitney, Anne M. ^{[5
]}

Gulvik, Christopher A. ^{[5
]}

Bell, Melissa E. ^{[5
]}

Rendueles, Olaya ^{[1
,2
]}

Cury, Jean ^{[1
,2
]}

Hugon, Perrine ^{[1
,2
]}

Clermont, Dominique ^{[9
]}

Enouf, Vincent ^{[10
]}

Loparev, Vladimir ^{[11
]}

Juieng, Phalasy ^{[11
]}

Monson, Timothy ^{[8
]}

Warshauer, David ^{[8
]}

Elbadawi, Lina I. ^{[12
,13
]}

Walters, Maroya Spalding ^{[14
]}

Crist, Matthew B. ^{[14
]}

Noble-Wang, Judith ^{[14
]}

Borlaug, Gwen ^{[13
]}

Rocha, Eduardo P. C. ^{[1
,2
]}

Criscuolo, Alexis ^{[3
]}

Touchon, Marie ^{[1
,2
]}

Davis, Jeffrey P. ^{[13
]}

Holt, Kathryn E. ^{[6
,7
]}

McQuiston, John R. ^{[5
]}

Brisse, Sylvain ^{[1
,2
,15
]}

机构：

[1] Inst Pasteur, Microbial Evolutionary Genom, F-75724 Paris, France

[2] CNRS, UMR 3525, F-75724 Paris, France

[3] Inst Pasteur, Hub Bioinformat & Biostat, C3BI, USR IP CNRS 3756, F-75724 Paris, France

[4] CNRS, UMS IFB Core 3601, F-91198 Gif Sur Yvette, France

[5] Ctr Dis Control & Prevent, Special Bacteriol Reference Lab, Bacterial Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30329 USA

[6] Univ Melbourne, Ctr Syst Genom, Parkville, Vic 3010, Australia

[7] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Dept Biochem & Mol Biol, Parkville, Vic 3010, Australia

[8] Wisconsin State Lab Hyg, Madison, WI 53718 USA

[9] Inst Pasteur, CIP, F-75724 Paris, France

[10] Inst Pasteur, Pasteur Int Bioresources Network PIBnet, P2M, F-75724 Paris, France

[11] Ctr Dis Control & Prevent, Div Sci Resources, Atlanta, GA 30329 USA

[12] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30329 USA

[13] Wisconsin Dept Hlth Serv, Div Publ Hlth, Madison, WI 53701 USA

[14] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30329 USA

[15] Inst Pasteur, Mol Prevent & Therapy Human Dis, F-75724 Paris, France

来源：

NATURE COMMUNICATIONS | 2017年 / 8卷

关键词：

BASE-EXCISION-REPAIR; CHRYSEOBACTERIUM-MENINGOSEPTICUM; KLEBSIELLA-PNEUMONIAE; EMERGING PATHOGEN; BACTERIAL GENOMES; SECRETION SYSTEMS; OXIDATIVE STRESS; COMB; NOV; DNA; SEQUENCE;

D O I：

10.1038/ncomms15483

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An atypically large outbreak of Elizabethkingia anophelis infections occurred in Wisconsin. Here we show that it was caused by a single strain with thirteen characteristic genomic regions. Strikingly, the outbreak isolates show an accelerated evolutionary rate and an atypical mutational spectrum. Six phylogenetic sub-clusters with distinctive temporal and geographic dynamics are revealed, and their last common ancestor existed approximately one year before the first recognized human infection. Unlike other E. anophelis, the outbreak strain had a disrupted DNA repair mutY gene caused by insertion of an integrative and conjugative element. This genomic change probably contributed to the high evolutionary rate of the outbreak strain and may have increased its adaptability, as many mutations in protein-coding genes occurred during the outbreak. This unique discovery of an outbreak caused by a naturally occurring mutator bacterial pathogen provides a dramatic example of the potential impact of pathogen evolutionary dynamics on infectious disease epidemiology.

引用

页数：12

共 15 条

[1] Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain
Amandine Perrin
Elise Larsonneur
Ainsley C. Nicholson
David J. Edwards
Kristin M. Gundlach
Anne M. Whitney
Christopher A. Gulvik
Melissa E. Bell
Olaya Rendueles
Jean Cury
Perrine Hugon
Dominique Clermont
Vincent Enouf
Vladimir Loparev
Phalasy Juieng
Timothy Monson
David Warshauer
Lina I. Elbadawi
Maroya Spalding Walters
Matthew B. Crist
Judith Noble-Wang
Gwen Borlaug
Eduardo P. C. Rocha
Alexis Criscuolo
Marie Touchon
Jeffrey P. Davis
Kathryn E. Holt
John R. McQuiston
Sylvain Brisse
[J]. Nature Communications, 8
[2] The Evolutionary Trend and Genomic Features of an Emerging Lineage of Elizabethkingia anophelis Strains in Taiwan
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