Molecular mechanisms and drug development in aquaporin water channel diseases: Aquaporins in the brain

被引：18
|
作者：
Kobayashi, H [1 ]
Yanagita, T [1 ]
Yokoo, H [1 ]
Wada, A [1 ]
机构：
[1] Miyazaki Univ, Miyazaki Med Coll, Dept Pharmacol, Kiyotake, Miyazaki 8891692, Japan
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2004年 / 96卷 / 03期
关键词：
aquaporin; brain; edema; glucocorticoid; lipid raft;
D O I：
10.1254/jphs.FMJ04004X5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Water homeostasis of the brain is essential for its neuronal activity. Changes in water content in the intra- and extra-cellular space affect ionic concentrations and therefore modify neuronal activity. Aquaporin (AQP) water channels may have a central role in keeping water homeostasis in the brain. Among AQP subtypes cloned in mammalian, only AQP1, AQP4, and AQP9 were identified in the brain. Changes in AQP expression may be correlated with edema formation of the brain. In this review, we describe the physiological function of AQPs and the regulatory mechanism of their expression in the brain.
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页码：264 / 270
页数：7
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