The novel histone deacetylase inhibitor NVP-LAQ824: an addition to the therapeutic armamentarium in leukemia?

被引:7
|
作者
Grant, S
机构
[1] Virginia Commonwealth Univ, Dept Med, Richmond, VA 23298 USA
[2] Virginia Commonwealth Univ, Dept Biochem, Richmond, VA 23298 USA
[3] Virginia Commonwealth Univ, Dept Pharmacol, Richmond, VA 23298 USA
关键词
D O I
10.1038/sj.leu.2403522
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1931 / 1933
页数:3
相关论文
共 50 条
  • [1] The novel histone deacetylase inhibitor NVP-LAQ824: an addition to the therapeutic armamentarium in leukemia?
    S Grant
    Leukemia, 2004, 18 : 1931 - 1933
  • [2] Preclinical efficacy, toxicology and pharmacokinetics of NVP-LAQ824, a novel synthetic histone deacetylase inhibitor
    Remiszewski, S
    Bontempo, J
    Cohen, P
    Cramer, JA
    Lassota, P
    Hug, M
    Perez, LB
    Thomas, HA
    Versace, R
    Atadja, P
    EUROPEAN JOURNAL OF CANCER, 2002, 38 : S98 - S99
  • [3] Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824
    Atadja, P
    Gao, L
    Kwon, P
    Trogani, N
    Walker, H
    Hsu, M
    Yeleswarapu, L
    Chandramouli, N
    Perez, L
    Versace, R
    Wu, A
    Sambucetti, L
    Lassota, P
    Cohen, D
    Bair, K
    Wood, A
    Remiszewski, S
    CANCER RESEARCH, 2004, 64 (02) : 689 - 695
  • [4] Discovery of NVP-LAQ824, a novel histone deacetylase inhibitor with in vitro and in vivo antitumor activity.
    Remiszewski, SW
    Sambucetti, LC
    Atadja, P
    Bair, KW
    Bontempo, J
    Cesarz, D
    Chandramouli, N
    Chen, R
    Dean, K
    Diamantidis, G
    Green, MA
    Howell, KL
    Kashi, R
    Kwon, P
    Lassota, P
    Mou, Y
    Nemzek, R
    Perez, LB
    Sorensen, E
    Taplin, F
    Trogani, N
    Versace, R
    Walker, H
    Weltchek-Engler, S
    Wood, AW
    Wu, A
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 224 : U46 - U46
  • [5] NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma
    Catley, L
    Weisberg, E
    Tai, YT
    Atadja, P
    Remiszewski, S
    Hideshima, T
    Mitsiades, N
    Shringarpure, R
    LeBlanc, R
    Chauhan, D
    Munshi, NC
    Schlossman, R
    Richardson, P
    Griffin, J
    Anderson, KC
    BLOOD, 2003, 102 (07) : 2615 - 2622
  • [6] Histone deacetylase inhibitor NVP-LAQ824 has significant activity against myeloid leukemia cells in vitro and in vivo
    E Weisberg
    L Catley
    J Kujawa
    P Atadja
    S Remiszewski
    P Fuerst
    C Cavazza
    K Anderson
    J D Griffin
    Leukemia, 2004, 18 : 1951 - 1963
  • [7] Histone deacetylase inhibitor NVP-LAQ824 has significant activity against myeloid leukemia cells in vitro and in vivo
    Weisberg, E
    Catley, L
    Kujawa, J
    Atadja, P
    Remiszewski, S
    Fuerst, P
    Cavazza, C
    Anderson, K
    Griffin, JD
    LEUKEMIA, 2004, 18 (12) : 1951 - 1963
  • [8] Mechanisms of radiosensitization by the inhibitor of histone deacetylase NVP-LAQ824 in human lung carcinoma tumor models
    Geng, L
    Fu, A
    Osusky, K
    Huamani, J
    Hallahan, DE
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2005, 63 (02): : S396 - S397
  • [9] Treatment of pancreatic cancer with two novel histone deacetylase inhibitors NVP-LAQ824 and NVP-LBH589
    Wiedmann, M.
    Haefner, M.
    Niederhagen, M.
    Schoppmeyer, K.
    Wittekind, C.
    Moebius, C.
    Mossner, J.
    Caca, K.
    JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
  • [10] Histone deacetylase inhibitor NVP-LAQ824 sensitizes human nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation
    Cuneo, Kyle C.
    Fu, Allie
    Osusky, Katherine
    Huamani, Jessica
    Hallahan, Dennis E.
    Geng, Ling
    ANTI-CANCER DRUGS, 2007, 18 (07) : 793 - 800