Synthesis and Cytotoxicity of Dinaphtho[2, 1-b:1',2'-d]furan Derivatives

被引：1

作者：

Song, Yongbin ^{[1
]}

Li, Dan ^{[2
]}

Yang, Yihui ^{[2
]}

Ji, Hongrui ^{[1
]}

Liu, Bo ^{[1
]}

机构：

[1] Harbin Univ Sci & Technol, Sch Chem & Environm Engn, Harbin 150040, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Coll Pharm, Harbin 150081, Heilongjiang, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 38卷 / 06期

关键词：

synthesis design; cytotoxicity; dinaphthofuran; NMR spectroscopy; BEARING; NAPHTHOFURAN;

D O I：

10.6023/cjoc201712018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In order to study the structure-activity relationships of dinaphthofuran derivatives, two series of dinaphtho[2,l-b:1', 2'-d]furan derivatives were synthesized. The structures of all compounds were identified by H-1 NMR, C-13 NMR, HRMS and IR spectra. The in vitro antitumor activity of the synthesized derivatives was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Most of them exhibited strong inhibitory activity on human hepatocellular carcinoma cell lines (HepG2 and SMMC-7721 cells), uterine cervix cancer Hela cells and acute promyelocytic leukemia NB4 cells. Compound 13k exhibited significant inhibitory activity against SMMC-7721 cells with IC50 vaue of 0.57 mu mol.L-1, much lower than 20.21 mu mol.L-1 of the positive control 5-Fu.

引用

页码：1516 / 1524

页数：9

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