Drug Discovery for PH-HFpEF: High Throughput Screening in Identification of SIRT3 Activators

被引：0
|
作者：
Levine, Andrea R.
Lear, Travis
Chen, Bill B.
Lai, Yen-Chun
Gladwin, Mark T.
机构：
来源：
CIRCULATION | 2017年 / 136卷
关键词：
Heart failure; adult; Metabolic syndrome; Pulmonary hypertension;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
20681
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Identification of Novel SIRT3 Activators as Therapeutic Prospects for PH-HFpEF
    Levine, A.
    Lear, T.
    Chen, B.
    Lai, Y.
    Gladwin, M. T.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
  • [2] Role of Skeletal Muscle SIRT3 in PH-HFpEF
    Lai, Y.
    Noda, K.
    Baust, J.
    Bachman, T.
    Goncharov, D.
    Goncharova, E. A.
    Mora, A. L.
    Gladwin, M. T.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
  • [3] Skeletal Muscle SIRT3 is Required for Nitrite- and Metformin-Mediated Reduction of PH-HFpEF
    Lai, Yen-Chun Charly
    Baust, Jeff
    Mora, Ana L.
    Gladwin, Mark T.
    CIRCULATION, 2017, 136
  • [4] Discovery of novel compounds as potent activators of Sirt3
    Reverdy, Celina
    Gitton, Gaetan
    Guan, Xiangying
    Adhya, Indranil
    Dumpati, Rama Krishna
    Roy, Samir
    Chall, Santu
    Ghosh, Anisha
    Errasti, Gauthier
    Delacroix, Thomas
    Chakrabarti, Raj
    BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 73
  • [5] Skeletal Muscle SIRT3 Deficiency-Mediated LOXL2 Secretion in Remote Pulmonary Vascular Remodeling and PH-HFpEF
    Lai, Y.
    Jheng, J.
    Bai, Y.
    Noda, K.
    Halliday, G.
    Huot, J.
    Bonetto, A.
    Goncharov, D.
    Goncharova, E. A.
    Simon, M.
    Rojas, M.
    Machado, R. F.
    Gladwin, M. T.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2022, 205
  • [6] SIRT3-AMPK Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes PH-HFpEF
    Lai, Yen-Chun
    Tabima, Diana M.
    Dube, John J.
    Goncharov, Dmitry A.
    Goncharova, Elena A.
    Tofovic, Stevan P.
    Mora, Ana L.
    Gladwin, Mark T.
    CIRCULATION, 2014, 130
  • [7] SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process
    Lambona, Chiara
    Zwergel, Clemens
    Valente, Sergio
    Mai, Antonello
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (03) : 1662 - 1689
  • [8] High throughput screening in drug discovery
    Carnero A.
    Clinical and Translational Oncology, 2006, 8 (7) : 482 - 490
  • [9] Identification of novel SIRT3 inhibitor scaffolds by virtual screening
    Salo, Heikki S.
    Laitinen, Tuomo
    Poso, Antti
    Jarho, Elina
    Lahtela-Kakkonen, Maija
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (10) : 2990 - 2995
  • [10] High throughput screening for new drug discovery
    Lin, BB
    JOURNAL OF FOOD AND DRUG ANALYSIS, 1995, 3 (04) : 233 - 241
12345