A stereocontrolled total synthesis of (±)-saframycin A

被引：12

作者：

Kimura, Shinya ^{[1
]}

Saito, Naoki ^{[1
]}

机构：

[1] Meiji Pharmaceut Univ, Grad Sch Pharmaceut Sci, 2-522-1 Noshio, Kiyose, Tokyo 2048588, Japan

来源：

TETRAHEDRON | 2018年 / 74卷 / 34期

关键词：

Total synthesis; Saframycin A; Antitumor antibiotic product; 1,2,3,4-Tetrahydroisoquinoline; Cytotoxicity; TRICYCLIC LACTAM INTERMEDIATE; ENANTIOSELECTIVE SYNTHESIS; SAFRAMYCIN-A; CHEMISTRY; (-)-SAFRAMYCIN-A; TETRAHYDROISOQUINOLINE; TRANSFORMATION;

D O I：

10.1016/j.tet.2018.07.017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A thirteen-step total synthesis of (+/-)-saframycin A from a tricyclic lactam intermediate is described. The key step of this total synthesis is the stereocontrolled construction of a pentacyclic saframycin framework via a modified Pictet-Spengler type cyclization generating a bis-carboxylic acid ester derivative, followed by decarboxylation. The cytotoxicity profiles are also presented. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：4504 / 4514

页数：11

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