Current perspectives of limbal-derived stem cells and its application in ocular surface regeneration and limbal stem cell transplantation

被引：29
|
作者：
Singh, Vivek [1 ]
Tiwari, Anil [2 ,3 ]
Kethiri, Abhinav Reddy [1 ]
Sangwan, Virender Singh [3 ]
机构：
[1] LV Prasad Eye Inst, Ctr Ocular Regenerat, Stem Cell Biol Lab, Hyderabad, Andhra Pradesh, India
[2] Univ Pittsburgh, Sch Med, Dept Ophthalmol, Pittsburgh, PA 15261 USA
[3] Dr Shroffs Char Eye Hosp, Dept Cornea & Uveitis, New Delhi, India
来源：
STEM CELLS TRANSLATIONAL MEDICINE | 2021年 / 10卷 / 08期
关键词：
corneal stromal stem cells; cultivated limbal epithelial transplantation; limbal stem cell deficiency; limbus; simple limbal epithelial transplantation; stem cells;
D O I：
10.1002/sctm.20-0408
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Limbal stem cells are involved in replenishing and maintaining the epithelium of the cornea. Damage to limbus due to chemical/physical injury, infections, or genetic disorders leads to limbal stem cell deficiency (LSCD) with partial or total vision loss. Presently, LSCD is treated by transplanting limbal stem cells from the healthy eye of the recipient, living-related, or the cadaveric donors. This review discusses limbal-derived stem cells, the importance of extracellular matrix in stem cell niche maintenance, the historical perspective of treating LSCD with their advantages and limitations, and our experience of limbal stem cell transplantation over the decades.
引用
收藏
页码：1121 / 1128
页数：8
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