The N-end rule and regulation of apoptosis

被引：92
|
作者：
Varshavsky, A [1 ]
机构：
[1] CALTECH, Div Biol, Pasadena, CA 91125 USA
来源：
NATURE CELL BIOLOGY | 2003年 / 5卷 / 05期
关键词：
D O I：
10.1038/ncb0503-373
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The ubiquitin-dependent N-end rule pathway targets proteins for degradation through their destabilizing N-terminal residues. This pathway is known to control the import of peptides, chromosome stability and cardiovascular development. A new report identifies yet another function of the N-end rule pathway: the regulation of apoptosis through degradation of Drosophila melanogaster DIAP1.
引用
收藏
页码：373 / 376
页数：4
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