Overexpression of DARPP-32 in colorectal adenocarcinoma

被引：24
|
作者：
Wang, MSJ [1 ]
Pan, Y [1 ]
Liu, N [1 ]
Guo, C [1 ]
Hong, L [1 ]
Fan, D [1 ]
机构：
[1] Fourth Mil Med Univ, Xijing Hosp, Inst Digest Dis, Xian 710032, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | 2005年 / 59卷 / 01期
关键词：
carcinogenesis; colorectal cancer; DARPP-32;
D O I：
10.1111/j.1742-1241.2004.00305.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Dopamine and cAMP-regulated phosphoprotein (DARPP)-32 is a phosphoprotein that is centrally involved in dopamine signalling pathways. It may play an important role in gastric tumorigenesis. Our aim is to investigate the expression of DARPP-32 protein in colorectal adenocarcinoma. The expression of DARPP-32 was evaluated by immunohistochemical SABC staining and Western blotting. DARPP-32 was specifically localised in colorectal epithelium. The expression of DARPP-32 in colorectal adenocarcinoma tissues 33/42, 78.57% was higher than that in normal colon epithelial tissues (31/60, 51.67%, p < 0.05). There was no significant relationship between the expression of DARPP-32 and the differentiation, metastasis and Dukes' stage of colorectal adenocarcinoma (p > 0.05). Both DARPP-32 and its truncated isoform t-DARPP were overexpressed in colorectal adenocarcinoma (t = 2.306, p = 0.028), while t-DARTP was more frequently detected. These results showed that DARPP-32 may play an important role in the regulation of normal colorectal epithelial biology and carcinogenesis. (C) 2004 Blackwell Publishing Ltd.
引用
收藏
页码：58 / 61
页数：4
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