Synthesis of some C-3,4,5-substituted 2,6-dimethyl-1,4-dihydropyridines (4-DHPs)

被引：9

作者：

Navarrete-Encina, Patricio A.

Squella, Juan A.

Carbajo, J.

Conde, B.

Nunez-Vergara, Luis J.

机构：

[1] Univ Chile, Adv Organ Synth Lab, Fac Chem & Pharmaceut Sci, Santiago, Chile

[2] Univ Chile, Bioelectrochem Lab, Fac Chem & Pharmaceut Sci, Santiago, Chile

来源：

SYNTHETIC COMMUNICATIONS | 2007年 / 37卷 / 12期

关键词：

cyclization; 1,4-dihydropyridines; nitrogen heterocycles;

D O I：

10.1080/00397910701357007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of C-3,4,5-substituted 2,6-dimethyl-1,4-dihydropyridines ( 1,4-DHPs) with pharmacological properties were prepared by a variation from the classical Hantzsch synthesis. The procedure involves treatment of the respective aldehyde with either ethyl-3-aminocrotonate or 3-aminocrotonitrile in anhydrous acetic acid at temperatures not exceeding 60 degrees C, thus minimizing by-product formation. The structures of title compounds were elucidated by H-1 NMR, C-13 NMR, FTIR, and elemental analysis.

引用

页码：2051 / 2060

页数：10

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