Proline-catalyzed asymmetric α-amination of aldehydes and ketones -: An astonishingly simple access to optically active α-hydrazino carbonyl compounds

被引：294
|
作者：
Duthaler, RO [1 ]
机构：
[1] Novartis Inst Biomed Res, CH-4002 Basel, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 09期
关键词：
amination; azodicarboxylates; catalysis; enantioselectivity; proline;
D O I：
10.1002/anie.200390283
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Simple, direct, and highly enantioselective α-amination of carbonyl compounds 1 with azodicarboxylates 2 no longer requires prior enolization of the substrate. The magic small-organic-molecule catalyst for this reaction in dichloromethane at room temperature is once again L-proline (3).
引用
收藏
页码：975 / 978
页数：4
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