Preoperative Concurrent Chemoradiotherapy Versus Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer: Phase II Randomized Study

被引：5

作者：

Wang, Xin ^{[1
]}

Zhao, Dong-Bing ^{[2
]}

Yang, Lin ^{[3
]}

Chi, Yihebali ^{[3
]}

Zhao, Hong ^{[2
]}

Jiang, Li-Ming ^{[4
]}

Jiang, Jun ^{[4
]}

Tang, Yuan ^{[1
]}

Li, Ning ^{[1
,5
,6
]}

Liu, Wen-Yang ^{[1
]}

Dou, Li-Zhou ^{[7
]}

Zou, Shuang-Mei ^{[8
]}

Xue, Li-Yan ^{[8
]}

Ren, Jian-Song ^{[9
]}

Tian, Yan-Tao ^{[2
]}

Che, Xu ^{[1
,10
]}

Guo, Chun-Guang ^{[2
]}

Bai, Xiao-Feng ^{[2
]}

Sun, Yue-Min ^{[2
]}

Wang, Shu-Lian ^{[1
]}

Song, Yong-Wen ^{[1
]}

Liu, Yue-Ping ^{[1
]}

Fang, Hui ^{[1
]}

Li, Ye-Xiong ^{[1
]}

Jin, Jing ^{[1
,5
,6
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Radiat Oncol,Canc Hosp, Beijing, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Pancreagastr Surg,Canc Hosp, Beijing, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Med Oncol,Canc Hosp, Beijing, Peoples R China

[4] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Radiol,Canc Hosp, Beijing, Peoples R China

[5] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Radiat Oncol,Canc Hosp, Shenzhen, Peoples R China

[6] Chinese Acad Med Sci & Peking Union Med Coll, Shenzhen Hosp, Shenzhen, Peoples R China

[7] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Endoscopy,Canc Hosp, Beijing, Peoples R China

[8] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Pathol,Canc Hosp, Beijing, Peoples R China

[9] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Off Canc Screening,Canc Hosp, Beijing, Peoples R China

[10] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Pancreagastr Surg,Canc Hosp, Shenzhen, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

neoadjuvant therapy; chemotherapy; chemoradiotherapy; gastric neoplasm; surgery; PERIOPERATIVE CHEMOTHERAPY; D2; GASTRECTOMY; OPEN-LABEL; OXALIPLATIN; ESOPHAGEAL; CAPECITABINE; SURGERY; TRIAL; RADIOTHERAPY; REGRESSION;

D O I：

10.3389/fonc.2022.870741

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

ObjectiveWe evaluated and compared the efficacy and safety of neoadjuvant chemoradiotherapy (NACRT) versus neoadjuvant chemotherapy (NACT) for locally advanced gastric cancer (LAGC) in a single-center randomized phase II trial. MethodsPatients with LAGC were enrolled and received either NACT or NACRT, followed by gastrectomy and adjuvant chemotherapy. The primary endpoint was an R0 resection rate. ResultsWe enrolled 75 patients: 75.7% (NACT, 28/37 patients) and 76.3% (NACRT, 29/38 patients) underwent surgery; R0 resection rates were 73.0% (27/37) and 73.7% (28/38), respectively. The NACRT group had significantly better major pathological response than the NACT group (37.9% vs 17.9%, p = 0.019). Between-group postoperative complications were not significantly different. The median follow-up was 59.6 months; 5-year overall survival (OS) rate was 50.1% (NACT) and 61.9% (NACRT); neither group reached the median OS; median progression-free survival was 37.3 and 63.4 months, respectively. ConclusionsS-1-based NACRT did not improve the R0 resection rate, although it presented better tumor regression with similar safety to NACT.

引用

页数：9

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