In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives

被引：287
|
作者：
Achar, Kavitha C. S. [1 ]
Hosamani, Kallappa M. [1 ]
Seetharamareddy, Harisha R. [1 ]
机构：
[1] Karnatak Univ, PG Dept Studies Chem, Dharwad 580003, Karnataka, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 05期
关键词：
2-(chloromethyl)-1H-benzimidazole derivatives; Analgesic; Anti-inflammatory; Benzimidazole derivatives; POTENTIAL ANTITUMOR AGENTS; ANTI-TUBERCULAR ACTIVITY; ONE-POT SYNTHESIS; VITRO; LIBRARIES; DRUGS;
D O I：
10.1016/j.ejmech.2010.01.029
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 2-methylaminobenzimidazole derivatives (1-11) were synthesized by the reaction of 2-(chloromethyl)-1H-benzimidazole derivatives with primary aromatic amines. All these compounds were characterized by IR, H-1 NMR, C-13 NMR, GC-MS and elemental analysis. The newly synthesized compounds were screened for analgesic and anti-inflammatory activities on acetic acid induced writhing in mice and carrageenan induced paw oedema in rats. Compounds (7) and (2) showed a potent analgesic (89% at 100 mg/kg b.w) and anti-inflammatory (100% at 100 mg/kg b.w) activities compared with standard drug Nimesulide (100% at 50 mg/kg b.w) respectively. The other compounds showed good analgesic and anti-inflammatory activities. (C) 2010 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：2048 / 2054
页数：7
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