Baicalin inhibits autophagy induced by influenza A virus H3N2

被引：68
|
作者：
Zhu, Hai-yan [1 ]
Han, Lei [1 ]
Shi, Xun-long [1 ]
Wang, Bao-long [1 ]
Huang, Hai [1 ]
Wang, Xin [1 ]
Chen, Dao-feng [2 ]
Ju, Dian-wen [1 ]
Feng, Mei-qing [1 ]
机构：
[1] Fudan Univ, Sch Pharm, Dept Biosynth, Shanghai 201203, Peoples R China
[2] Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China
来源：
ANTIVIRAL RESEARCH | 2015年 / 113卷
基金：
中国国家自然科学基金;
关键词：
Influenza A virus; Autophagy; Baicalin; H3N2; NS1; PROTEIN; PATHWAY; GROWTH; IDENTIFICATION; SUPPRESSION; INFECTION; APOPTOSIS; TARGET; CELLS; AKT;
D O I：
10.1016/j.antiviral.2014.11.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Baicalin, a natural product isolated from Scutellaria radix, has been reported to have significant in vivo and in vitro anti-influenza virus activity, but the underlying mechanism remains poorly understood. In this study, we found that baicalin inhibited autophagy induced by influenza virus A3/Beijing/30/95 (H3N2) in both A549 and Ana-1 cells. The results showed that H3N2 induced autophagy by suppressing mTOR signaling pathway, which however could be significantly inhibited by baicalin. Baicalin could suppress the expression of Atg5-Atg12 complex and LC3-II, and attenuate autophagy induced by starvation. Thus, the inhibition of autophagy induced by virus may account for the antiviral activities of baicalin against H3N2. Autophagy may be a potential marker in developing novel anti-influenza drugs. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：62 / 70
页数：9
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