Suppression of immunoglobulin E-mediated anaphylactic reaction by Alpinia oxyphylla in rats

被引：14
|
作者：
Kim, SH
Choi, YK
Jeong, HJ
Kang, HU
Moon, G
Shin, TY
Kim, HM [1 ]
机构：
[1] Wonkwang Univ, Ctr Oriental Med Sci, Coll Pharm, Dept Oriental Pharm, Iksan 570749, Chonbuk, South Korea
[2] Woosuk Univ, Coll Pharm, Chonju 565701, Chonbuk, South Korea
[3] Wonkwang Univ, Coll Oriental Med, Iksan 570749, Chonbuk, South Korea
来源：
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2000年 / 22卷 / 02期
关键词：
Alpinia oxyphylla water extract; anaphylactic reaction; histamine; anti-dnitrophenyl IgE antibody; tumor necrosis factor-alpha;
D O I：
10.3109/08923970009016420
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We investigated the effect of Alpinia oxyphylla water extract (AOWE) on immunoglobulin E (IgE)-mediated anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody. AOWE dose-dependently suppressed passive cutaneous anaphylaxis (PCA) when intraperitoneally or orally administered. On the other hand, it showed weak suppressive activity when administred intravenously. AOWE dose-dependently suppressed anaphylactic histamine release from rat peritoneal mast cells (RPMC) activated by anti-DNP IgE antibody. However, AOWE had a significant augmenting effect on anti-DNP IgE antibody-induced tumor necrosis factor-alpha secretion from RPMC. These results indicated that AOWE may possess strong antianaphylactic action and also suggest that differential activity following administration routes may be caused by difference of bioavailability.
引用
收藏
页码：267 / 277
页数：11
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