Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10

被引：3
|
作者：
Yamashita, T
Tomiyama, T
Li, Q
Numata, H
Mori, H
机构：
[1] Osaka City Univ, Sch Med, Dept Neurosci, Osaka 5458585, Japan
[2] Osaka City Univ, Grad Sch Sci, Dept Bio & Geosci, Osaka 5588585, Japan
来源：
FEBS LETTERS | 2005年 / 579卷 / 01期
关键词：
tau; splicing; stem-loop model; linear model; FTDP-17;
D O I：
10.1016/j.febslet.2004.11.090
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tau exon 10 (E10) splicing is a crucial event in its developmental change of tau isoform and tauopathy. To investigate the splicing mechanism, we isolated and compared mouse tau genomic sequence with human sequence. We identified a new element in mouse intron 10 (110) to suppress E10 splicing, which was located just after the stem-loop region previously proposed in human sequence and found to potentially form another stem-loop. Human 110 with a mutation (+29G to A) causing a decreased E10 splicing was also predicted to form similar double stem-loop, suggesting that this element is universally involved in regulation of 10 splicing. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：241 / 244
页数：4
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