Optimization of a potent stapled helix peptide that binds to Replication Protein A

被引:0
|
作者
Waterson, Alex G. [1 ]
Frank, Andreas O. [1 ]
Vandgamudi, Bhavatarini [1 ]
Feldkamp, Michael D. [1 ]
Souza-Fagundes, Elaine M. [1 ]
Luzwick, Jessica W. [1 ]
Cortez, David [1 ]
Olejniczak, Edward T. [1 ]
Rossanese, Olivia W. [1 ]
Chazin, Walter J. [1 ]
Fesik, Stephen W. [1 ]
机构
[1] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA
关键词
D O I
10.1158/1538-7445.AM2014-3232
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3232
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A
    Frank, Andreas O.
    Vangamudi, Bhavatarini
    Feldkamp, Michael D.
    Souza-Fagundes, Elaine M.
    Luzwick, Jessica W.
    Cortez, David
    Olejniczak, Edward T.
    Waterson, Alex G.
    Rossanese, Olivia W.
    Chazin, Walter J.
    Fesik, Stephen W.
    JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (06) : 2455 - 2461
  • [2] A stapled BID BH3 helix directly binds and activates BAX
    Walensky, Loren D.
    Pitter, Kenneth
    Morash, Joel
    Oh, Kyoung Joon
    Barbuto, Scott
    Fisher, Jill
    Smith, Eric
    Verdine, Gregory L.
    Korsmeyer, Stanley J.
    MOLECULAR CELL, 2006, 24 (02) : 199 - 210
  • [3] Human replication protein A melts a DNA triple helix structure in a potent and specific manner
    Wu, Yuliang
    Rawtani, Nina
    Thazhathveetil, Arun Kalliat
    Kenny, Mark K.
    Seidman, Michael M.
    Brosh, Robert M., Jr.
    BIOCHEMISTRY, 2008, 47 (18) : 5068 - 5077
  • [4] Towards the development of a peptide-PROTAC conjugate targeting a viral protein: Rational design and optimization of a stapled alpha-helical peptide that binds HPV16 E2 protein
    Richardson, Stacie
    Hartman, Matthew
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [5] Ultrashort All-Hydrocarbon Stapled α-Helix Amphiphile as a Potent and Stable Antimicrobial Compound
    Shao, Changxuan
    Jian, Qiao
    Li, Bowen
    Zhu, Yongjie
    Yu, Weikang
    Li, Zhongyu
    Shan, Anshan
    JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (16) : 11414 - 11427
  • [6] Construction of a Stapled α-Helix Peptide Library Displayed on Phage for the Screening of Galectin-3-Binding Peptide Ligands
    Anananuchatkul, Teerapat
    Chang, Iou Ven
    Miki, Takayuki
    Tsutsumi, Hiroshi
    Mihara, Hisakazu
    ACS OMEGA, 2020, 5 (11): : 5666 - 5674
  • [7] Optimization of stapled peptide inhibitors of the estrogen receptor/coactivator interaction
    Moore, Terry
    Speltz, Thomas
    Mayne, Christopher
    Danes, Jeanne
    Fanning, Sean
    David, Brian
    Greene, Geoffrey
    Frasor, Jonna
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 255
  • [8] Optimization of the loop length for folding of a helix-loop-helix peptide
    Suzuki, N
    Fujii, N
    TETRAHEDRON LETTERS, 1999, 40 (33) : 6013 - 6017
  • [9] Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors
    Adak, Anindyasundar
    Das, Gaurav
    Gupta, Varsha
    Khan, Juhee
    Mukherjee, Nabanita
    Mondal, Prasenjit
    Roy, Rajsekhar
    Barman, Surajit
    Gharai, Prabir Kumar
    Ghosh, Surajit
    JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (20) : 13866 - 13878
  • [10] Replication protein A binds preferentially to immunostimulatory oligonucleotides.
    Stacey, KJ
    Sester, DP
    Murphy, KM
    Sweet, MJ
    Hume, DA
    FASEB JOURNAL, 2000, 14 (06): : A1049 - A1049