Residual hormone levels in used contraceptive rings as a measurement of adherence to vaginal ring use

被引：9
|
作者：
Haaland, Richard E. [1 ]
Holder, Angela [1 ]
Evans-Strickfaden, Tammy [1 ]
Nyagol, Beatrice [2 ]
Makanga, Mumbi [2 ]
Oyaro, Boaz [2 ]
Humwa, Felix [2 ]
Williams, Tiffany [3 ]
McLellan-Lemal, Eleanor [1 ]
Desai, Mitesh [1 ]
Huey, Michael J. [4 ]
机构：
[1] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd NE, Atlanta, GA 30329 USA
[2] KEMRI CDC Res Field Stn, POB 1578, Kisumu, Kenya
[3] Ctr Dis Control & Prevent, ICF Int, Div HIV AIDS Prevent, Atlanta, GA 30329 USA
[4] Emory Univ, Sch Med, Hlth Serv, 1525 Clifton Rd, Atlanta, GA 30322 USA
来源：
CONTRACEPTION | 2017年 / 95卷 / 06期
关键词：
Vaginal ring; Adherence; Contraception; Multipurpose technology; HIV; ETHINYL ESTRADIOL; ACCEPTABILITY; PREVENTION; EFFICACY;
D O I：
10.1016/j.contraception.2017.03.011
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: This study sought to measure residual contraceptive hormone levels in vaginal rings as an adherence marker for monitoring product use in clinical trials. Study design: Residual etonogestrel and ethinyl estradiol levels from used NuvaRings (R) of 26 self-reported adherent women enrolled in a clinical trial of vaginal ring acceptability were compared to those from 16 women who used NuvaRing (R) as their contraceptive choice. Results: Twenty-one (81%) clinical trial rings had contraceptive hormone levels within the range of those used as a contraceptive choice. Five returned rings had unused or discordant levels of residual contraceptive hormones. Conclusion: Residual vaginal ring drug levels could help assess adherence in clinical trials. Published by Elsevier Inc.
引用
收藏
页码：602 / 604
页数：3
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