ABO-Incompatible Heart Transplant in Infants: A UNOS Database Review

Background. ABO-incompatible (ABOi) plantation (HT) in infants has been used ing list time and mortality with outcomes ABO compatible (ABOc). We sought to ABOi listing and transplantation for infants United Network for Organ Sharing registry uate its influence on outcomes. Methods. We reviewed infants listed United Network for Organ Sharing registry We compared demographic and clinical waiting list duration, graft survival, and from rejection between patients listed ABOc. Cochran-Armitage trend test, univariate metric statistical methods, and Kaplan-Meier used to analyze the data. Results. During the study period, 2787 patients were listed for HT, 53% of whom were listed for ABOi. Median waiting list time for patients in blood group O receiving an ABOi transplant was significantly shorter (P < .0001). Among the 1862 patients who received HT, 15% were ABOi. The incidence of ABOi HT also increased over time. The pretransplant anti-A and anti-B titers in the ABOi group did not significantly affect outcomes. There was no difference in the incidence of rejection in the first year after transplant and no significant difference in posttransplant survival Conclusions. The number of infants listed and transplanted as ABOi has gradually increased over the past decade, with a significantly decreased waiting list time for ABOi transplants in blood group O. At 1 year after transplant, rejection was comparable between the ABOi and ABOc groups and there was no significant difference in survival. (C) 2021 by The Society of Thoracic Surgeons