Dynamic thiol/disulphide homeostasis in children with febrile seizure

Purpose: Febrile seizure (FS) is the most common type of seizure in children and its etiopathogenesis is still not fully understood. We aimed to investigate the thiol/disulphide balance in children who had experienced FS in our study. Methods: We included 40 FS and 40 control group subjects in the study. The total thiol, native thiol, and disulphide levels were measured and the disulphide/native thiol, disulphide/total thiol and native thiol/total thiol ratios were calculated in both groups. Results: The mean age and gender distribution of the patients and control group subjects were similar. The total thiol level was lower in the FS group than the control group with no statistical significance (p = 0.123). Native thiol was significantly lower in the FS group than the control group (p = 0.031). The disulphide level and the disulphide/native thiol and disulphide/total thiol ratios were statistically significantly higher in the FS group than the control group while the native thiol/total thiol ratio was lower. Conclusion: The fact that the disulphide level was higher and the native thiol level lower in the FS group than the control group suggests that the thiol/disulphide balance may have shifted in favor of oxidants and that oxidants may have a role in FS pathogenesis. (C) 2018 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.