In the alarming context of antibiotic resistance, we explored the antibacterial potential of French mushrooms against wild-type and multidrug-resistant (MDR) bacteria. In order to accelerate the discovery of promising compounds, screenings were carried out by TLC-direct bioautography. A total of 70 extracts from 31 mushroom species were evaluated against five wild-type bacteria: Staphylococcus epidermidis, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa. This first screening revealed that 95% of the extracts contained antibacterial compounds. Generally, it was observed that EtOAc extracts exhibited more active compounds than methanolic extracts. In addition, all extracts were overall more active against Gram-positive bacteria than against Gram-negative strains. The most promising mushroom extracts were then screened against various multidrug-resistant strains of S. aureus and E. coli. Activity was globally less on MDR strains; however, two mushroom species, Fomitopsis pinicola and Scleroderma citrinum, still contained several compounds inhibiting the growth of these MDR pathogenic bacteria. Stearic acid was identified as a ubiquitous compound contributing to the antibacterial defence of mushrooms. This screening revealed the potential of macromycetes as a source of antibacterial compounds; further assays are necessary to consider fungal compounds as promising drugs to counter antibiotic resistance.
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Autonomous Univ Nuevo Leon, Fac Chem Sci, Av Univ S-N,Ciudad Univ, San Nicolas De Los Garza 66451, Nuevo Leon, Mexico
Univ Basque Country, UPV EHU, Dept Organ Chem 2, Leioa 48940, SpainAutonomous Univ Nuevo Leon, Fac Chem Sci, Av Univ S-N,Ciudad Univ, San Nicolas De Los Garza 66451, Nuevo Leon, Mexico
Nocedo-Mena, Deyani
Garza-Gonzalez, Elvira
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Autonomous Univ Nuevo Leon, Univ Hosp Dr Jose Eleuterio Gonzalez, Gastroenterol Serv, Av Gonzalitos & Madero S-N, Monterrey 64460, Nuevo Leon, MexicoAutonomous Univ Nuevo Leon, Fac Chem Sci, Av Univ S-N,Ciudad Univ, San Nicolas De Los Garza 66451, Nuevo Leon, Mexico
Garza-Gonzalez, Elvira
Gonzalez-Ferrara, Mauricio
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PACALLI S RL CV, Monterrey, Nuevo Leon, MexicoAutonomous Univ Nuevo Leon, Fac Chem Sci, Av Univ S-N,Ciudad Univ, San Nicolas De Los Garza 66451, Nuevo Leon, Mexico
Gonzalez-Ferrara, Mauricio
del Rayo Camacho-Corona, Maria
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Autonomous Univ Nuevo Leon, Fac Chem Sci, Av Univ S-N,Ciudad Univ, San Nicolas De Los Garza 66451, Nuevo Leon, MexicoAutonomous Univ Nuevo Leon, Fac Chem Sci, Av Univ S-N,Ciudad Univ, San Nicolas De Los Garza 66451, Nuevo Leon, Mexico
机构:
King Saud Univ, Coll Sci, Dept Bot & Microbiol, POB 22452, Riyadh 11495, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Bot & Microbiol, POB 22452, Riyadh 11495, Saudi Arabia
Alkufeidy, Roua M.
Al Farraj, Dunia A.
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King Saud Univ, Coll Sci, Dept Bot & Microbiol, POB 22452, Riyadh 11495, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Bot & Microbiol, POB 22452, Riyadh 11495, Saudi Arabia
Al Farraj, Dunia A.
Aljowaie, Reem M.
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King Saud Univ, Coll Sci, Dept Bot & Microbiol, POB 22452, Riyadh 11495, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Bot & Microbiol, POB 22452, Riyadh 11495, Saudi Arabia
Aljowaie, Reem M.
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Ali, M. Ajmal
Elshikh, Mohamed S.
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King Saud Univ, Coll Sci, Dept Bot & Microbiol, POB 22452, Riyadh 11495, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Bot & Microbiol, POB 22452, Riyadh 11495, Saudi Arabia