TAK-875, a Novel, Orally Available GPR40 Agonist, Augments Glucose-Dependent Insulin Secretion and Improves Both Postprandial and Fasting Hyperglycemia in Type 2 Diabetic Rats

被引:0
|
作者
Tsujihata, Yoshiyuki
Itou, Ryo
Suzuki, Masami
Harada, Ayako
Negoro, Nobuyuki
Takeuchi, Koji
Yamada, Yukio
Hazama, Masatoshi
机构
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:A165 / A165
页数:1
相关论文
共 25 条
  • [1] TAK-875, a Novel GPR40 Agonist, Improves Both Postprandial and Fasting Hyperglycemia in Japanese Patients with Type 2 Diabetes
    Araki, Takahiro
    Hirayama, Masashi
    Hiroi, Shinzo
    Kaku, Kohei
    DIABETES, 2011, 60 : A86 - A86
  • [2] TAK-875, an Orally Available G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist, Enhances Glucose-Dependent Insulin Secretion and Improves Both Postprandial and Fasting Hyperglycemia in Type 2 Diabetic Rats
    Tsujihata, Yoshiyuki
    Ito, Ryo
    Suzuki, Masami
    Harada, Ayako
    Negoro, Nobuyuki
    Yasuma, Tsuneo
    Momose, Yu
    Takeuchi, Koji
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2011, 339 (01): : 228 - 237
  • [3] TAK-875, a GPR40 Agonist, Improves Postprandial Hyperglycemia Additively With Sulfonylurea and Is Effective in Rats With Sulfonylurea Failure
    Ito, Ryo
    Tsujihata, Yoshiyuki
    Suzuki, Masami
    Matsuda-Nagasumi, Kae
    Miyawaki, Kazumasa
    Negoro, Nobuyuki
    Takeuchi, Koji
    DIABETES, 2012, 61 : A294 - A294
  • [4] A selective GPR40 agonist, TAK-875, augments glucose-dependent insulin secretion without affecting glucagon secretion in isolated rat and human islets
    Yashiro, H.
    Tsujihata, Y.
    Takeuchi, K.
    Hazama, M.
    Rorsman, P.
    DIABETOLOGIA, 2010, 53 : S107 - S108
  • [5] A selective GPR40 agonist, TAK-875, stimulates glucose-dependent insulin secretion without beta cell toxicity and decreases blood glycosylated haemoglobin levels in diabetic rats
    Takeuchi, K.
    Tsujihata, Y.
    Ito, R.
    Suzuki, M.
    Harada, A.
    Hazama, M.
    DIABETOLOGIA, 2010, 53
  • [6] Activation of GPR40 by TAK-875 Ameliorates Hyperglycemia via Increasing Glucose-Dependent Insulin Secretion in Streptozotocin Treated Rats Fed a High-Fat Diet
    Qi, Yong
    Chi, Chengyuan
    Zhou, Wen
    Zhang, Weibo
    Zheng, Zhenyu
    Cui, Jisong
    DIABETES, 2014, 63 : A614 - A614
  • [7] Fasiglifam/TAK-875, a Selective GPR40 Agonist, Improves Hyperglycemia in Rats Unresponsive to Sulfonylureas and Acts Additively with Sulfonylureas
    Ito, Ryo
    Tsujihata, Yoshiyuki
    Suzuki, Masami
    Miyawaki, Kazumasa
    Matsuda, Kae
    Takeuchi, Koji
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2016, 357 (01): : 217 - 227
  • [8] HD-6277, a Novel GPR40 Agonist, Improves Glucose Homeostasis and Enhanced Glucose-Dependent Insulin Secretion in Beta Cells and Type 2 Diabetic Rats
    Kim, Daehoon
    Kim, Chun Hwa
    Choi, Hyo Sun
    Yang, Goeun
    Kang, Seung Jun
    Lee, Sun Hee
    Lim, Kwan Soo
    Park, Min Ah
    Kim, Doo Young
    Rhee, Jae Keol
    DIABETES, 2018, 67
  • [9] TAK-875, a GPR40 Agonist, in Combination with Metformin Improves Glycemic Control and β-Cell Function in Zucker Diabetic Fatty Rats
    Ito, Ryo
    Tsujihata, Yoshiyuki
    Nagasumi, Kae
    Negoro, Nobuyuki
    Takeuchi, Koji
    DIABETES, 2011, 60 : A275 - A275
  • [10] Pharmacokinetic/Pharmacodynamic Modeling of TAK-875, a Novel GPR40 Agonist, in Japanese Patients with Type 2 Diabetics
    Matsuno, Kumi
    Hirayama, Masashi
    Araki, Takahiro
    Hiroi, Shinzo
    Kaku, Kohei
    DIABETES, 2011, 60 : A616 - A616