EFFECT OF THE ANTI-C1S HUMANIZED ANTIBODY TNT009 AND ITS PARENTAL MOUSE VARIANT TNT003 ON HLA ANTIBODY-INDUCED COMPLEMENT ACTIVATION - A PRECLINICAL IN VITRO STUDY

被引：0

作者：

Wahrmann, Markus ^{[1
]}

Muehlbacher, Jakob ^{[1
]}

Marinova, Lena ^{[1
]}

Regele, Heinz ^{[1
]}

Huttary, Nicole ^{[1
]}

Eskandary, Farsad ^{[1
]}

Cohen, Gerald ^{[1
]}

Fischer, Gottfried F. ^{[1
]}

Parry, Graham C. ^{[2
]}

Gilbert, James C. ^{[2
]}

Panicker, Sandip ^{[2
]}

Boehmig, Georg A. ^{[1
]}

机构：

[1] Med Univ Vienna, Vienna, Austria

[2] True North Therapeut Inc, San Francisco, CA USA

来源：

HLA | 2017年 / 89卷 / 06期

关键词：

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：342 / 342

页数：1

共 19 条

[1] Effect of the Anti-C1s Humanized Antibody TNT009 and Its Parental Mouse Variant TNT003 on HLA Antibody-Induced Complement Activation-A Preclinical In Vitro Study
Wahrmann, M.
Muehlbacher, J.
Marinova, L.
Regele, H.
Huttary, N.
Eskandary, F.
Cohen, G.
Fischer, G. F.
Parry, G. C.
Gilbert, J. C.
Panicker, S.
Boehmig, G. A.
AMERICAN JOURNAL OF TRANSPLANTATION, 2017, 17 (09) : 2300 - 2311
[2] TNT003, a Novel Anti-C1s Monoclonal Antibody, Inhibits Anti-HLA Antibody Induced Complement Deposition
Thomas, K.
Valenzuela, N.
Parry, G.
Panicker, S.
Reed, E.
TRANSPLANTATION, 2014, 98 : 461 - 461
[3] TNT009 and Its Parental Mouse Monoclonal Antibody TNT003 Target Complement Component C1s and Effectively Block Alloantibody-Induced Classical Complement Pathway Activation - The Preclinical Experience.
Wahrmann, M.
Muehlbacher, J.
Regele, H.
Eskandary, F.
Gilbert, J.
Panicker, S.
Boehmig, G.
AMERICAN JOURNAL OF TRANSPLANTATION, 2016, 16 : 720 - 720
[4] TNT003, a Novel Anti-C1s Monoclonal Antibody, Inhibits Anti-HLA Antibody Induced Complement Deposition.
Thomas, K.
Valenzuela, N.
Parry, G.
Panicker, S.
Reed, E.
AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 : 461 - 461
[5] The Anti-C1s Antibody TNT003 Prevents Complement Activation in the Skin Induced by Bullous Pemphigoid Autoantibodies
Kasprick, Anika
Holtsche, Maike M.
Rose, Eileen L.
Hussain, Sami
Schmidt, Enno
Petersen, Frank
Panicker, Sandip
Ludwig, Ralf J.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2018, 138 (02) : 458 - 461
[6] An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA
Thomas, K. A.
Valenzuela, N. M.
Gjertson, D.
Mulder, A.
Fishbein, M. C.
Parry, G. C.
Panicker, S.
Reed, E. F.
AMERICAN JOURNAL OF TRANSPLANTATION, 2015, 15 (08) : 2037 - 2049
[7] MULTIPLE DOSING OF ANTI-C1S ANTIBODY TNT009 EFFECT ON HLA ANTIBODY-TRIGGERED COMPLEMENT ACTIVATION IN HEALTHY VOLUNTEERS AND KIDNEY TRANSPLANT RECIPIENTS WITH ANTIBODY-MEDIATED REJECTION
Muehlbacher, J.
Jilma, B.
Wahrmann, M.
Eskandary, F.
Gilbert, James. C.
Panicker, S.
Boehmig, G.
TRANSPLANT INTERNATIONAL, 2017, 30 : 13 - 13
[8] PHARMACOKINETIC/PHARMACODYNAMIC ANALYSIS OF HUMAN ANTI-C1S ANTIBODY (TNT009) AND CLASSICAL COMPLEMENT PATHWAY (CP) ACTIVITY
Jilma, B.
Gilbert, J.
Nix, D.
Chang, C.
Beliveau, M.
Marier, J.
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2017, 101 (S1) : S58 - S58
[9] BLOCKADE OF HLA ANTIBODY-TRIGGERED CLASSICAL COMPLEMENT ACTIVATION BY HIGH-AFFINITY HUMANIZED MONOCLONAL ANTI-C1S ANTIBODY TNT009-RESULTS OF A PHASE 1 TRIAL
Muehlbacher, J.
Jilma, B.
Wahrmann, M.
Marinova, L.
Eskandary, F.
Gilbert, J. C.
Panicker, S.
Boehmig, G. A.
TRANSPLANT INTERNATIONAL, 2016, 29 : 10 - 10
[10] TNT003, A MONOCLONAL ANTIBODY AGAINST THE COMPLEMENT COMPONENT C1S, INHIBITED IN VITRO EFFICIENT ALLOANTIBODY-INDUCED CLASSICAL COMPLEMENT ACTIVATION
Muehlbacher, J.
Marinova, L.
Huttary, N.
Regele, H.
Eskandary, F.
Gilbert, J.
Panicker, S.
Boehmig, G. A.
Wahrmann, M.
TRANSPLANT INTERNATIONAL, 2015, 28 : 12 - 12

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