Insights into the reaction of transplatin with DNA and proteins:: Methionine-mediated formation of histidine-guanine trans-Pt(NH3)2 cross-links

被引：22
|
作者：
Marchán, V [1 ]
Pedroso, E [1 ]
Grandas, A [1 ]
机构：
[1] Univ Barcelona, Fac Quim, Dept Quim Organ, E-08028 Barcelona, Spain
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2004年 / 10卷 / 21期
关键词：
cross-links; isomers; mass spectrometry; oligonucleotides; peptides; platinum; transplatin;
D O I：
10.1002/chem.200400470
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Simultaneous exposure of transplatin to polypeptides and DNA was mimicked by using a model peptide-oligonucleotide conjugate. Initially formed methionine-guanine chelates evolved into adducts with histidine-guanine trans-Pt(NH3)(2) cross-links that differed in constitution and stability from those formed by reaction of the same conjugate with the anticancer drug cisplatin. This finding may be due to different capacities of the two diamminedichloroplatinum(II) complexes to interfere with biological processes and may explain their differing cytotoxicities.
引用
收藏
页码：5369 / 5375
页数：7
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