Identification of a Racially Dimorphic Variant in the Human Platelet PAR4 Thrombin Receptor Altering Platelet Function and Pharmacologic Inhibition

被引:0
|
作者
Edelstein, Leonard C. [1 ]
Simon, Lukas M. [2 ]
Lindsay, Cory R. [1 ]
Kong, Xiango [1 ]
Montoya, Raul Teruel [1 ]
Tourdot, Benjamin E. [1 ]
Chen, Edward [2 ]
Ma, Lin [1 ]
Coughlin, Shaun R. [3 ]
Nieman, Marvin T. [4 ]
Holinstat, Michael [1 ]
Shaw, Chad [2 ]
Bray, Paul F. [1 ]
机构
[1] Thomas Jefferson Univ, Philadelphia, PA 19107 USA
[2] Baylor Coll Med, Houston, TX 77030 USA
[3] UCSF, San Francisco, CA USA
[4] Case Western Reserve Univ, Cleveland, OH 44106 USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:3
相关论文
共 50 条
  • [1] Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race
    Edelstein, Leonard C.
    Simon, Lukas M.
    Lindsay, Cory R.
    Kong, Xianguo
    Teruel-Montoya, Raul
    Tourdot, Benjamin E.
    Chen, Edward S.
    Ma, Lin
    Coughlin, Shaun
    Nieman, Marvin
    Holinstat, Michael
    Shaw, Chad A.
    Bray, Paul F.
    BLOOD, 2014, 124 (23) : 3450 - 3458
  • [2] Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP
    Kong, Xianguo
    Simon, Lukas M.
    Holinstat, Michael
    Shaw, Chad A.
    Bray, Paul F.
    Edelstein, Leonard C.
    THROMBOSIS AND HAEMOSTASIS, 2017, 117 (05) : 962 - 970
  • [3] Racial Differences In Thrombin-Induced Human Platelet PAR4 Reactivity
    Edelstein, Leonard C.
    Simon, Lukas M.
    Montoya, Raul Teruel
    Holinstat, Michael
    Chen, Edward
    Woodley, Angela Bergeron
    Kong, Xiango
    Nagalla, Srikanth
    Mohandas, Narla
    Cohen, David
    Dong, Jing-fei
    Shaw, Chad A.
    Bray, Paul F.
    BLOOD, 2013, 122 (21)
  • [4] A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling
    Rodriguez, Benjamin A. T.
    Bhan, Arunoday
    Beswick, Andrew
    Elwood, Peter C.
    Niiranen, Teemu J.
    Salomaa, Veikko
    Tregouet, David-Alexandre
    Morange, Pierre-Emmanuel
    Civelek, Mete
    Ben-Shlomo, Yoav
    Schlaeger, Thorsten
    Chen, Ming-Huei
    Johnson, Andrew D.
    AMERICAN JOURNAL OF HUMAN GENETICS, 2020, 107 (02) : 211 - 221
  • [5] Molecular study on the interactions between extracellular fragments of platelet thrombin receptor PAR4 and thrombin exosites and functional effects on platelet activation
    Centellas, Sanchez D.
    Selegard, R.
    Enander, K.
    Lindahl, T.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2013, 11 : 1145 - 1145
  • [6] Inhibition of PAR4 signaling in ethanol-attenuation of platelet function.
    Kasuda, S
    Sakurai, Y
    Shima, M
    Takeyama, M
    Hatake, K
    Yoshioka, A
    BLOOD, 2004, 104 (11) : 60B - 60B
  • [7] Platelet thrombin receptors PAR1 and PAR4 act in a synergistic manner
    Oberg, K., V
    Kulsum, S.
    Boknas, N.
    Ramstrom, S.
    Lindahl, T. L.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 : 629 - 629
  • [8] Platelet PAI-1 release is dependent on both thrombin receptor PAR1 and PAR4
    Nylander, M.
    Lofgren, E.
    Grenegard, M.
    Lindahl, T. L.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 : 323 - 323
  • [9] Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome
    Covic, L
    Singh, C
    Smith, H
    Kuliopulos, A
    THROMBOSIS AND HAEMOSTASIS, 2002, 87 (04) : 722 - 727
  • [10] Platelet responsiveness to PAR4 activation in a healthy population and its inhibition by a potent and selective PAR4 antagonist
    Downes, K.
    Astle, W.
    McKinney, H.
    Kempster, C.
    Batista, J.
    Garner, S.
    Allegretto, N.
    Ouwehand, W. H.
    Yang, J.
    EUROPEAN HEART JOURNAL, 2016, 37 : 1017 - 1017