Invasive Fungal Infections in Acute Promyelocytic Leukemia on Dual Differentiating Agents: Real World Data

被引：5

作者：

Yanamandra, Uday ^{[1
]}

Karunakaran, Parathan ^{[2
]}

Khadwal, Alka ^{[2
]}

Prakash, Gaurav ^{[2
]}

Lad, Deepesh ^{[2
]}

Naseem, Shano ^{[3
]}

Varma, Neelam ^{[3
]}

Chakrabarti, Arunaloke ^{[4
]}

Varma, Subhash ^{[2
]}

Malhotra, Pankaj ^{[2
]}

机构：

[1] Army Hosp Res & Referral, Dept Haematol & Stem Cell Transplant, Delhi 110010, India

[2] PGIMER, Dept Internal Med & Clin Hematol, Chandigarh 160012, UT, India

[3] PGIMER, Dept Hematopathol, Chandigarh 160012, UT, India

[4] PGIMER, Dept Med Microbiol, Chandigarh 160012, UT, India

来源：

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION | 2018年 / 34卷 / 03期

关键词：

APL; Fungal infection; ATO; ATRA; ARSENIC TRIOXIDE; RETINOIC ACID; DISEASES; THERAPY;

D O I：

10.1007/s12288-017-0894-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Invasive fungal infection (IFI) in patients with acute promyelocytic leukemia (APL) is a common phenomenon in developing countries. In a systematic study (Dual Inducing Differentiating agents-Indian Trial: DID-IT) using dual differentiating agents (ATO and ATRA) in 98 APL patients at our center we report 18.3% incidence of IFI (n-18). Among all cases of IFI three were definitive, 14 were probable and one was possible IFI. We conclude that incidence of IFI in APL is affected by environmental and therapy related factors and mere usage of dual differentiating agents need not necessarily decrease the incidence of fungal infections.

引用

页码：466 / 468

页数：3

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