Characterization of micellar systems produced by new amphiphilic conjugates of poly(ethylene glycol)

被引：2
|
作者：
Pignatello, R. [1 ]
Panto, V. [1 ]
Basile, L. [2 ]
Leonardi, A. [1 ]
Guarino, C. [3 ]
La Rosa, C. [4 ]
机构：
[1] Univ Catania, Dipartimento Sci Farmaco, Sez Tecnol Farmaceut, Catania, Italy
[2] EtnaLead srl, Catania, Italy
[3] Ist Super Sanita, Ctr Nazl ONDICO, Rome, Italy
[4] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2014年 / 40卷 / 11期
关键词：
CMC; conductimetry; lipoamino acids; micelles; COLLOIDAL DRUG CARRIERS; BILE-SALT-LECITHIN; LIPOAMINO ACIDS; POLYMERIC MICELLES; DELIVERY-SYSTEMS; SURFACE MODIFIERS; NANOPARTICLES; DERIVATIVES; ABSORPTION; MEMBRANES;
D O I：
10.3109/03639045.2013.828226
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This study proposes polymeric micelles produced using new amphiphilic conjugates between amino- or carboxy-mPEG(2000) and three different alpha-lipoamino acids (PEG-LAA). The characterization of these colloidal systems showed CMC values, in the order of 10(-5) M, that are interesting in the view of an in vivo administration. The PEG-LAA micelles also showed a good stability at 37 degrees C and upon dilution in aqueous media. Using a colored probe as a model lipophilic compound, the loading efficiency and in vitro release profile were also outlined.
引用
收藏
页码：1463 / 1467
页数：5
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