Obesity and nonalcoholic fatty liver disease

被引：95
|
作者：
Angulo, Paul [1 ]
机构：
[1] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Miles & Shirley Fiterman Ctr Digest Dis, Rochester, MN 55905 USA
来源：
NUTRITION REVIEWS | 2007年 / 65卷 / 06期
关键词：
diabetes; dyslipidemia; insulin resistance; nonalcoholic fatty liver disease (NAFLD); obesity;
D O I：
10.1301/nr.2007.jun.S57-S63
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
With the increasing prevalence of obesity and type 2 diabetes mellitus in the general population, nonalcoholic fatty liver disease (NAFLD) has become a common diagnosis in clinical practice. Insulin resistance and oxidative stress play an important role in NAFLD development and progression. NAFLD affects one in three adults and one in 10 children/adolescents in the United States. Mortality in patients with NAFLD is significantly higher than in the general population of same age and gender with liver-related complications. Lifestyle intervention may improve NAFLD, but medications that increase insulin sensitivity and the antioxidant defenses in the liver deserve evaluation in carefully controlled trials.
引用
收藏
页码：S57 / S63
页数：7
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