Oral Cancer 1 Genetics and the Role of Precision Medicine

被引：20

作者：

Li, Chia-Cheng ^{[1
]}

Shen, Zhen ^{[2
]}

Bavarian, Roxanne ^{[2
,3
]}

Yang, Fan ^{[2
]}

Bhattacharya, Aditi ^{[4
]}

机构：

[1] Harvard Sch Dent Med, Dept Oral Med Infect & Immun, 188 Longwood Ave, Boston, MA 02115 USA

[2] Harvard Sch Dent Med, 188 Longwood Ave, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Div Oral Med & Dent, Francis St, Boston, MA 02115 USA

[4] NYU, Dept Oral & Maxillofacial Surg, Coll Dent, East 24th St, New York, NY 10010 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2020年 / 29卷 / 01期

关键词：

Oral cancer; Oral squamous cell carcinoma; Malignant transformation; Epigenetics; Omics technology; Big data; Personalized medicine; Precision medicine; SQUAMOUS-CELL CARCINOMA; LYMPH-NODE METASTASIS; NECK-CANCER; STEM-CELLS; TUMOR MICROENVIRONMENT; HUMAN-PAPILLOMAVIRUS; FIELD CANCERIZATION; ION CHROMATOGRAPHY; MOLECULAR-BIOLOGY; POOR-PROGNOSIS;

D O I：

10.1016/j.soc.2019.08.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oral squamous cell carcinoma (OSCC) is one of the leading cancers in the world. OSCC patients are managed with surgery and/or chemoradiation. Prognoses and survival rates are dismal, however, and have not improved for more than 20 years. Recently, the concept of precision medicine was introduced, and the introduction of targeted therapeutics demonstrated promising outcomes. This article reviews the current understanding of initiation, progression, and metastasis of OSCC from both genetic and epigenetic perspectives. In addition, the applications and integration of omics technologies in biomarker discovery and drug development for treating OSCC are reviewed.

引用

页码：127 / +

页数：20

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