Maintenance of HIV-specific central and effector memory CD4 and CD8 T cells requires antigen persistence

被引：10

作者：

Sester, Urban

Sester, Martina

Koehler, Hans

Pees, Hans W.

Gaertner, Barbara C.

Wain-Hobson, Simon

Bocharov, Gennady

Meyerhans, Andreas ^{[1
]}

机构：

[1] Univ Saarland, Dept Virol, D-66421 Homburg, Germany

[2] Univ Saarland, Dept Internal Med 4, D-66421 Homburg, Germany

[3] Univ Saarland, Dept Internal Med 1, D-66421 Homburg, Germany

[4] Inst Pasteur, Unite Retrovirol Mol, Paris, France

[5] Russian Acad Sci, Inst Numer Math, Moscow, Russia

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2007年 / 23卷 / 04期

关键词：

D O I：

10.1089/aid.2006.0234

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The HIV-specific central and effector CD4 and CD8 memory T cell populations disappear from the peripheral blood of infected individuals under highly active antiretroviral therapy ( HAART) with a mean half-life of 6.0 and 7.7 months, respectively. By contrast, cytomegalovirus ( CMV)-specific responses are stable or increase. The striking quantitative differences between T cell memory to two persistent viral infections are instructive as to how antigen dosage contributes to the maintenance of antigen-specific memory T cell responses in humans.

引用

页码：549 / 553

页数：5

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