Metallization of Single-Stranded Poly by Zn2+ Ions in Neutral Solutions

被引：0

作者：

Sorokin, Victor A. ^{[1
]}

Valeev, Vladimir A. ^{[1
]}

Usenko, Evgeniya L. ^{[1
]}

Andrushchenko, Valery V. ^{[2
]}

机构：

[1] Natl Acad Sci Ukraine, BI Verkin Inst Low Temp Phys & Engn, UA-61103 Kharkov, Ukraine

[2] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-16610 Prague, Czech Republic

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2014年 / 118卷 / 43期

关键词：

DIVALENT METAL-IONS; CONFORMATIONAL EQUILIBRIUM; DNA; BINDING; POLYNUCLEOTIDES; COMPLEXES;

D O I：

10.1021/jp5065903

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Metallization of single-stranded polyinosinic acid (polyI) by Zn2+ ions at pH 7.0 was studied by differential UV spectroscopy at different temperatures. It was found that polyI is metallized at N7 and N1 atoms of hypoxanthine. The concentration dependence of the degree of binding of Zn2+ ions to both N7 and N1 sites was obtained, and the corresponding binding constants were determined. Metallization of N1 occurs due to Zn2+ substituting the imino protons and is effective not only at alkaline but also at neutral pH. This makes multistranded polyI-based systems more promising candidates for use in nanoelectronics than natural DNA sequences, metallization of which can be achieved only at alkaline pH.

引用

页码：12360 / 12365

页数：6

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