Small noncoding RNAs and male infertility

被引:23
|
作者
Gou, Lan-Tao [1 ,2 ]
Dai, Peng [1 ,2 ]
Liu, Mo-Fang [1 ,2 ]
机构
[1] Univ Chinese Acad Sci, State Key Lab Mol Biol, Ctr RNA Res, Shanghai, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai Key Lab Mol Androl, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
MALE GERM-CELLS; PIWI-INTERACTING RNAS; MICRORNA EXPRESSION PROFILES; SMALL INTERFERING RNAS; CHROMATOID BODY; MESSENGER-RNA; PIRNA PATHWAY; TUDOR DOMAIN; ENDOGENOUS SIRNAS; MAMMALIAN-CELLS;
D O I
10.1002/wrna.1252
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Small noncoding RNAs (ncRNAs) are a novel class of gene regulators that modulate gene expression at transcriptional, post-transcriptional, and epigenetic levels, and they play crucial roles in almost all cellular processes in eukaryotes. Recent studies have indicated that several types of small noncoding RNAs, including microRNAs (miRNAs), endo-small interference RNAs (endo-siRNAs), and Piwi-interacting RNAs (piRNAs), are expressed in the male germline and are required for spermatogenesis in animals. In this review, we summarize the recent knowledge of these small noncoding RNAs in male germ cells and their biological functions and mechanisms of action in animal spermatogenesis. WIREs RNA 2014, 5:733-745. doi: 10.1002/wrna.1252 For further resources related to this article, please visit the . Conflict of interest: The authors have declared no conflicts of interest for this article.
引用
收藏
页码:733 / 745
页数:13
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